Glassy Dynamics and Memory Effects in an Intrinsically Disordered Protein Construct
Glassy Dynamics and Memory Effects in an Intrinsically Disordered Protein Construct
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本质上无序的蛋白质结构中的玻璃动力学和记忆效应
DOI：
10.1103/physrevlett.125.058001
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发表时间：
2020
影响因子：
8.6
通讯作者：
Saleh, Omar A.
中科院分区：
文献类型：
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作者：
Morgan, Ian L.;Avinery, Ram;Rahamim, Gil;Beck, Roy;Saleh, Omar A.
球状蛋白质中的玻璃状、非指数松弛通常归因于内在无序蛋白质中缺失的构象行为。然而，我们发现，一个无序的蛋白质结构的单分子显示两个签名的玻璃态动力学，对数松弛和Kovacs记忆效应，在施加的张力的变化。我们将此归因于链中存在多个独立的局部结构，我们用正确预测松弛力依赖性的模型证实了这一点。这里建立的机制可能适用于其他无序蛋白质。
Glassy, nonexponential relaxations in globular proteins are typically attributed to conformational behaviors that are missing from intrinsically disordered proteins. Yet, we show that single molecules of a disordered-protein construct display two signatures of glassy dynamics, logarithmic relaxations and a Kovacs memory effect, in response to changes in applied tension. We attribute this to the presence of multiple independent local structures in the chain, which we corroborate with a model that correctly predicts the force dependence of the relaxation. The mechanism established here likely applies to other disordered proteins.