Invasion of veins in renal cell carcinoma - frequency, correlation and prognosis.
Invasion of veins in renal cell carcinoma - frequency, correlation and prognosis.
复制标题
肾细胞癌静脉侵犯——频率、相关性和预后。
DOI：
10.1159/000474103
复制
发表时间：
1983
期刊：
影响因子：
23.4
通讯作者：
P. Hermanek
中科院分区：
文献类型：
--
作者：
W. Hoehn;P. Hermanek
在426例手术切除的肾细胞癌中，197例（46.2%）证实了肉眼可见的静脉侵犯。肿瘤侵犯下腔静脉占4.0%，侵犯肾静脉主干占24.4%，仅侵犯肾静脉主干占18.1%。在132例（31.0%）无肿瘤的主要肾分支中，组织学可显示静脉侵犯。肾静脉侵犯与其他病理参数如组织学分级、肿瘤直径、局部扩散和淋巴结转移之间存在显著相关性。肾静脉侵犯的证据影响预后：肉眼检查确定的静脉侵犯的年龄校正5年生存率为33.6 +/- 8.5%;组织学确定的静脉侵犯的年龄校正5年生存率为62.3 +/- 11.9%，无静脉侵犯的年龄校正5年生存率为89.0 +/- 10.3%。静脉侵犯应细分为组织学证据和宏观证据，因为这会导致显著不同的存活率。因此，有必要对UICC分类标准进行准确定义并将其标准化，并在下一期UICC分类中牢记在心。
Of 426 operatively removed renal cell carcinomas, macroscopic vein invasion was proven in 197 cases, i.e. 46.2%. The inferior vena cava contained tumor in 4.0%, the trunk of the renal vein in 24.4%, and in 18.1% only the major branches of the renal vein were found invaded. In 132 patients (31.0%) with tumor-free major renal branches, vein invasion could be demonstrated histologically. Statistically significant correlations could be found comparing renal vein invasion and other pathological parameters as histological grade, tumor diameter, local spread and lymphatic metastases. Proof of renal vein invasion affects prognosis: age-corrected 5-year survival rates amounted to 33.6 +/- 8.5% in macroscopically determined vein invasion; 62.3 +/- 11.9% in histologically determined vein invasion, and 89.0 +/- 10.3% without vein invasion. Vein invasion should be subdivided into an only histological and a macroscopical group of evidence, because significantly different survival rates will result. Therefore, an exact definition of the UICC classification criteria and a standardized usage are necessary and should be kept in mind for the next issue of the UICC classifications.