Increased ornithine decarboxylase activity in murine sarcoma virus infected cells
Increased ornithine decarboxylase activity in murine sarcoma virus infected cells
复制标题
鼠肉瘤病毒感染细胞中鸟氨酸脱羧酶活性增加
作者：
A. Gazdar;H. Stull;L. Kilton;U. Bachrach
多胺的生物合成是细胞增殖过程中最早发生的事件之一1，2，其进行的速度受到鸟氨酸脱羧酶(ODC)的限制，ODC是一种催化鸟氨酸生成腐胺的酶。在静息细胞中，ODC水平很低，但很稳定，在生长开始后，ODC水平迅速增加4，5。某些肿瘤细胞，包括肝癌，神经母细胞瘤和SV40转化细胞3-7，ODC水平升高。快速生长的肝癌比生长缓慢的肝癌有更高的酶水平6。在劳斯肉瘤病毒(RSV)转化过程中，ODC水平的升高先于形态变化。
POLYAMINE biosynthesis is one of the earliest events occurring during cellular proliferation1,2, and the rate at which it proceeds3 is limited by ornithine decarboxylase (ODC), an enzyme which catalyses the formation of putrescine from ornithine. ODC levels are low, but stable, in resting cells, and a large increase in activity occurs rapidly after the onset of growth4,5. Elevated ODC levels occur in certain tumour cells, including hepatoma, neuroblastoma and SV40-transformed cells3–7. Fast growing hepatomas have higher enzyme levels than slow growing ones6. During Rous sarcoma virus (RSV) transformation, elevation of ODC levels precedes morphological change8.