Beneficial effect of combined aspiration and interstitial laser therapy in patients with benign cystic thyroid nodules:: a pilot study
Beneficial effect of combined aspiration and interstitial laser therapy in patients with benign cystic thyroid nodules:: a pilot study
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DOI：
10.1259/bjr/40698061
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发表时间：
2006-12-01
影响因子：
2.6
通讯作者：
Hegedus, L.
中科院分区：
文献类型：
--
作者：
Dossing, H.;Bennedbaek, F. N.;Hegedus, L.
本研究的目的是评估囊肿抽吸联合超声引导下间质激光光凝（ILP）对良性囊性甲状腺结节复发率和体积的影响。10例甲状腺功能正常的门诊患者，其孤立的细胞学良性部分囊性甲状腺结节引起局部不适，被分配接受囊肿抽吸术，随后进行超声引导下的ILP，并随访12个月。ILP在连续超声引导下进行，输出功率为2.5-3.5 W。结节的体积通过超声波和测定抽吸的囊液的量来评估，从而计算固体部分的体积。随访包括超声检查和甲状腺功能测定。在视觉模拟量表上评价压力和外观投诉。随访期间，囊性结节的中位初始体积从9.6 ml [6.8;15.5（四分位数）]降至3.5 ml [2.7;9.0（四分位数）]（p=0.0001），中位囊肿体积从3.0 ml [2.0;6.0（四分位数）]降至0 ml [0;0.5（四分位数）]（p=0.0001）。囊肿部分复发定义为囊肿体积> 1 ml。在10例患者中，有8例没有复发的囊性部分。压力症状和美容投诉均显着减少。唯一的副作用是几天的轻微疼痛或压痛。我们的研究表明，完整的囊肿抽吸和随后的超声引导下良性囊性甲状腺结节的ILP是一种可行和安全的技术，导致在实体和囊性成分的体积显着减少。需要进行大规模的前瞻性随机研究。
The aim of this study was to evaluate the effect of combined cyst aspiration and ultrasound-guided interstitial laser photocoagulation (ILP) on recurrence rate and the volume of benign cystic thyroid nodules. 10 euthyroid outpatients with a solitary and cytologically benign partially cystic thyroid nodule causing local discomfort were assigned to cyst aspiration followed by ultrasound-guided ILP and followed for 12 months. The ILP was performed under continuous ultrasound-guidance and with an output power of 2.5-3.5 W. The volume of the nodules was assessed by means of ultrasound and determination of the amount of aspirated cyst fluid, thereby calculating the volume of the solid part. Follow-up included ultrasound and determination of thyroid function. Pressure and cosmetic complaints were evaluated on a visual analogue scale. The median initial volume of the cystic nodule decreased from 9.6 ml [6.8;15.5 (quartiles)] to 3.5 ml [2.7;9.0 (quartiles)] (p=0.0001), and the median cyst volume from 3.0 ml [2.0;6.0 (quartiles)] to 0 ml [0;0.5 (quartiles)] (p=0.0001) during follow-up. Recurrence of the cystic part was defined as a cyst volume > 1 ml. In eight of 10 patients there was no recurrence of the cystic part. Both pressure symptoms and cosmetic complaints were significantly reduced. The only side effect was mild pain or tenderness for a few days. Our study suggests that complete cyst aspiration and subsequent ultrasound-guided ILP of benign cystic thyroid nodules is a feasible and safe technique, resulting in a significant reduction in the volume of both the solid and the cystic component. A large-scale prospective randomized study is warranted.