Design and analysis of stepped wedge cluster randomized trials
Design and analysis of stepped wedge cluster randomized trials
复制标题
DOI：
10.1016/j.cct.2006.05.007
复制
发表时间：
2007-02-01
影响因子：
2.2
通讯作者：
Hughes, James P.
中科院分区：
文献类型：
--
作者：
Hussey, Michael A.;Hughes, James P.
群集随机试验（CRT）通常用于在个体随机化不可能或出于逻辑、财务或伦理原因不可取的情况下评估治疗或干预措施。虽然关于CRT使用“平行”设计（即I组随机分配至每种治疗）的文献数量显著且快速增长，但仅描述了使用交叉设计的CRT的几个示例。在这篇文章中，我们讨论了一种特殊类型的交叉CRT的设计和分析-阶梯楔-并提供了一个例子，它的使用。(c)2006年爱思唯尔公司All rights reserved.
Cluster randomized trials (CRT) are often used to evaluate therapies or interventions in situations where individual randomization is not possible or not desirable for logistic, financial or ethical reasons. While a significant and rapidly growing body of literature exists on CRTs utilizing a "parallel" design (i.e. I clusters randomized to each treatment), only a few examples of CRTs using crossover designs have been described. In this article we discuss the design and analysis of a particular type of crossover CRT - the stepped wedge - and provide an example of its use. (c) 2006 Elsevier Inc. All rights reserved.