Reproductive and hormonal risk factors for postmenopausal luminal, HER-2-overexpressing, and triple-negative breast cancer.
Reproductive and hormonal risk factors for postmenopausal luminal, HER-2-overexpressing, and triple-negative breast cancer.
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DOI：
10.1002/cncr.23786
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发表时间：
2008-10-01
期刊：
影响因子：
6.2
通讯作者：
Li, Christopher I.
中科院分区：
文献类型：
--
作者：
Phipps, Amanda I.;Malone, Kathleen E.;Porter, Peggy L.;Daling, Janet R.;Li, Christopher I.
Molecular profiling studies have identified subtypes of breast cancer that can be approximately classified by estrogen receptor (ER), progesterone receptor (PR), and HER2-neu (HER2) expression. These molecular subtypes are prognostically significant, but differences in their etiologic profiles have not been established. Reproductive factors may plausibly be differentially related to risk of different breast cancer subtypes since these factors are presumed to impact exposure to endogenous sex hormones. We pooled two population-based case-control studies of breast cancer in women aged 55-79 years, for an analysis including 1,476 controls and 1,023 luminal, 39 HER2-overexpressing, and 78 triple-negative cases. Polytomous logistic regression was used to compare each case group to controls. Associations varied by molecular subtype. Early age at menarche was only associated with risk of HER2-overexpressing disease [odds ratio (OR)=2.7, 95% confidence interval (CI): 1.4-5.5], while breastfeeding for 6 months or longer was only protective for luminal and triple-negative disease (OR=0.8, 95% CI:0.6-1.0 and OR=0.5, 95% CI: 0.3-0.9, respectively). Both late age at menopause and use of estrogen plus progestin hormone therapy were only associated with risk of luminal disease (OR=1.6, 95% CI: 1.1-2.2, and OR=1.7, 95% CI: 1.3-2.1, respectively). No differences in risks associated with parity or age at first live birth were observed by subtype. Certain reproductive factors may have a greater impact on risk of certain molecular subtypes of disease compared to others. Future studies that further define the etiology of breast cancer subtypes will add to our biological understanding of the disease.
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影响因子：
3.8
作者：
Yang, Xiaohong R.;Sherman, Mark E.;Garcia-Closas, Montserrat
通讯作者：
Garcia-Closas, Montserrat
影响因子：
2.7
作者：
BEGG, CB;GRAY, R
通讯作者：
GRAY, R
影响因子：
6.2
作者：
Tjonneland, A;Christensen, J;Mellemkjær, L
通讯作者：
Mellemkjær, L
DOI：
10.1073/pnas.0932692100
发表时间：
2003-07-08
影响因子：
11.1
作者：
Sorlie, T;Tibshirani, R;Botstein, D
通讯作者：
Botstein, D
DOI：
10.1186/bcr1512
发表时间：
2006
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Alexe G;Alexe S;Axelrod DE;Bonates TO;Lozina II;Reiss M;Hammer PL
通讯作者：
Hammer PL