Diet and cataract -: The Blue Mountains Eye Study
Diet and cataract -: The Blue Mountains Eye Study
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DOI：
10.1016/s0161-6420(99)00024-x
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发表时间：
2000-03-01
期刊：
影响因子：
13.7
通讯作者：
Smith, W
中科院分区：
文献类型：
--
作者：
Cumming, RG;Mitchell, P;Smith, W
目的：研究大量和微量营养素（包括抗氧化维生素）与老年人三种主要类型白内障之间的关系。设计：基于人群的横断面研究。参与者：居住在澳大利亚悉尼附近城市社区的2900名49至97岁的人。测试：食物频率问卷和透镜摄影。主要结果测量：透镜照片进行了分级的存在和严重程度的皮质，核，后囊下白内障。结果：较高的蛋白质，维生素A，烟酸，硫胺素，核黄素的摄入量与核性白内障的患病率降低。在调整了多个已知的白内障风险因素后，摄入量最高的五分之一组与摄入量最低的五分之一组相比的比值比为0.5（95%置信区间[Cl]，0.3-0.8）蛋白质，0.5（95% CI，0.3-0.9）维生素A，0.6（95% CI，0.4-0.9）烟酸，0.6（95%CI，0.4-0.9），核黄素为0.5（95%CI，0.3-0.9）。多不饱和脂肪的摄入与皮质性白内障患病率降低相关。没有营养物质与后囊下白内障。结论：核的透镜是特别敏感的营养缺乏，蛋白质，维生素A，烟酸，硫胺素，核黄素保护核性白内障在这项研究中。(C)2000年由美国眼科学会。
Purpose: To investigate relationships between a wide range of macro- and micronutrients, including antioxidant vitamins, and the three main types of cataract in older people.Design: Population-based cross-sectional study.Participants: Two thousand nine hundred people aged 49 to 97 years living in an urban community near Sydney, Australia.Testing: Food frequency questionnaires and lens photography.Main Outcome Measure: Lens photographs were graded for presence and severity of cortical, nuclear, and posterior subcapsular cataracts.Results: Higher intakes of protein, vitamin A, niacin, thiamin, and riboflavin were associated with reduced prevalence of nuclear cataract. After adjusting for multiple known cataract risk factors, the odds ratios for those in the highest intake quintile groups compared to those in the lowest intake quintiles were 0.5 (95% confidence interval [Cl], 0.3-0.8) for protein, 0.5 (95% CI, 0.3-0.9) for vitamin A, 0.6 (95% CI, 0.4-0.9) for niacin, 0.6 (95% CI, 0.4-0.9) for thiamin, and 0.5 (95% CI, 0.3-0.9) for riboflavin, Intake of polyunsaturated fats was associated with reduced prevalence of cortical cataract. No nutrients were associated with posterior subcapsular cataract.Conclusions: The nucleus of the lens is particularly sensitive to nutrient deficiencies, Protein, vitamin A, niacin, thiamin, and riboflavin protected against nuclear cataract in this study. (C) 2000 by the American Academy of Ophthalmology.