IMMUNOHISTOCHEMICAL INDICATIONS OF GASTRIN RELEASING PEPTIDE BOMBESIN-LIKE IMMUNOREACTIVITY IN THE NERVOUS-SYSTEM OF THE RAT - CODISTRIBUTION WITH SUBSTANCE P-LIKE IMMUNOREACTIVE NERVE-TERMINAL SYSTEMS AND COEXISTENCE WITH SUBSTANCE P-LIKE IMMUNOREACTIVITY IN DORSAL-ROOT GANGLION-CELL BODIESRA
IMMUNOHISTOCHEMICAL INDICATIONS OF GASTRIN RELEASING PEPTIDE BOMBESIN-LIKE IMMUNOREACTIVITY IN THE NERVOUS-SYSTEM OF THE RAT - CODISTRIBUTION WITH SUBSTANCE P-LIKE IMMUNOREACTIVE NERVE-TERMINAL SYSTEMS AND COEXISTENCE WITH SUBSTANCE P-LIKE IMMUNOREACTIVITY IN DORSAL-ROOT GANGLION-CELL BODIESRA
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DOI：
10.1016/0304-3940(83)90498-6
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发表时间：
1983-01-01
影响因子：
2.5
通讯作者：
CUELLO, AC
中科院分区：
文献类型：
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作者：
FUXE, K;AGNATI, LF;CUELLO, AC
弱到强胃泌素释放肽蛙皮素（GRP-BN）样免疫反应性被发现在精细的静脉曲张的神经末梢系统的低到高密度的几个部分的中枢神经系统。最高密度的强免疫反应终末被发现在边缘层和胶状质的脊髓，并在三叉神经脊束核的部分。形态计量学分析表明，GRP-BN样免疫反应阳性神经元和P物质（SP），而不是生长抑素（SS）免疫反应阳性神经元在脊髓中显著共分布。SP和GRP-BN样免疫反应在三叉神经节和脊神经节细胞中共存。在某些SP免疫反应阳性的神经终末系统中，GRP-BN样免疫反应可能与SP共存。
Weak to strong gastrin releasing peptide-bombesin (GRP-BN)-like immunoreactivity was found in fine varicose nerve terminal systems of low to high densities in several parts of the CNS. The highest densities of strongly immunoreactive terminals were found in the marginal layer and in the substantia gelatinosa of the spinal cord, and in parts of the nucleus tractus spinalis nervi trigemini. Morphometrical analysis in the spinal cord demonstrates that GRP-BN-like-immunoreactive and substance P (SP), but not somatostatin (SS)-immunoreactive nerve temrinals strikingly codistribute. Coexistence of SP and GRP-BN-like immunoreactivities was demonstrated in trigeminal and spinal ganglion nerve cells. GRP-BN-like immunoreactivity may coexist with SP in certain SP-immunoreactive nerve terminal systems.