Severe schistosomiasis in the absence of interleukin-4 (IL-4) is IL-12 independent
Severe schistosomiasis in the absence of interleukin-4 (IL-4) is IL-12 independent
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DOI：
10.1128/iai.69.1.589-592.2001
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发表时间：
2001-01-01
影响因子：
3.1
通讯作者：
Pearce, EJ
中科院分区：
文献类型：
--
作者：
Patton, EA;Brunet, LR;Pearce, EJ
白细胞介素-4（IL-4）依赖性Th 2应答允许野生型小鼠在感染曼氏血吸虫后存活。在缺乏IL-4的情况下，受感染的小鼠会产生Th 1样促炎反应，发展成严重的疾病并死亡。在该系统中，Th 1应答和发病率均不依赖于IL-12。
An interleukin-4 (IL-4)-dependent Th2 response allows wild-type mice to survive infection with the parasite Schistosoma mansoni. In the absence of IL-4, infected mice mount a Th1-like proinflammatory response, develop severe disease, and succumb. Neither the Th1 response nor morbidity is IL-12 dependent in this system.