MicroRNAs in malignant progression
MicroRNAs in malignant progression
复制标题
DOI：
10.4161/cc.7.5.5547
复制
发表时间：
2008-03-01
期刊：
影响因子：
4.3
通讯作者：
Weinberg, Robert A.
中科院分区：
文献类型：
--
作者：
Ma, Li;Weinberg, Robert A.
越来越多的证据表明，某些microRNAs(MiRNAs)通过调节控制细胞周期、细胞凋亡和分化等细胞过程的基因，在肿瘤发生中发挥因果作用。最近，我们实验室的工作表明，一种特定的miRNA可以导致癌细胞入侵和转移。本文综述了近年来几个实验室关于miRNAs在肿瘤发病机制和转移转移中的作用的研究进展，重点是促进转移的microRNA miR-10b，并讨论了未来的方向和临床应用的可能性。
A growing body of evidence suggests that certain microRNAs (miRNAs) play causal roles in tumorigenesis by regulating genes that control cellular processes such as cell cycle, apoptosis and differentiation. Lately, work in our laboratory has revealed that a specific miRNA can cause cancer cells to invade and metastasize. Here we review recent progress made in several laboratories concerning the roles played by miRNAs in cancer pathogenesis and metastatic spread, with the focus on the pro-metastatic microRNA, miR-10b and discuss the future directions and possibilities for clinical applications.