Comparison of the growth-promoting effects of testosterone and 7-alpha-methyl-19-nor-testosterone (MENT) on the prostate and levator ani muscle of LPB-tag transgenic mice.
Comparison of the growth-promoting effects of testosterone and 7-alpha-methyl-19-nor-testosterone (MENT) on the prostate and levator ani muscle of LPB-tag transgenic mice.
复制标题
比较睾酮和 7-α-甲基-19-去甲睾酮 (MENT) 对 LPB 标签转基因小鼠前列腺和提肛肌的生长促进作用。
DOI：
10.1002/pros.20354
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Cunningham,GR
中科院分区：
文献类型：
--
作者：
Shao,TC;Li,HL;Kasper,S;Matusik,R;Ittmann,M;Cunningham,GR
BACKGROUND7‐α‐methyl‐19‐nortestosterone (MENT) is being considered for androgen replacement in testosterone deficient men and as a male contraceptive. Because androgenic effects on the prostate are a major concern, we have evaluated MENT in a transgenic model of prostate cancer.METHODSLPB‐Tag mice were castrated and infused with testosterone (T; 5 or 30 µg/day) or MENT (5 or 30 µg/day) for 4 weeks. Prostate, seminal vesicle, and levator ani muscle (LAM) weights were compared.RESULTSAt an equivalent dose, MENT maintained or stimulated the mean weights of these organs more than T. However, the dorsolateral prostate/LAM ratio of weights did not favor MENT, but DNA/mg tissue and Ki 67 immunostaining suggested that MENT may increase DNA less than T.CONCLUSIONSMENT is more potent than T in maintaining or stimulating prostate, seminal vesicle, and LAM. Using doses that resulted in comparable stimulation of the levator ani muscle, MENT had similar effect on prostate weight, but increased DNA/mg prostate less than T in this transgenic mouse model of prostate cancer. © 2005 Wiley‐Liss, Inc.
