Augmented reinforcer value and accelerated habit formation after repeated amphetamine treatment
Augmented reinforcer value and accelerated habit formation after repeated amphetamine treatment
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DOI：
10.1016/j.euroneuro.2006.12.005
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发表时间：
2007-07-01
影响因子：
5.6
通讯作者：
Vanderschuren, L. J. M. J.
中科院分区：
文献类型：
--
作者：
Nordquist, R. E.;Voorn, P.;Vanderschuren, L. J. M. J.
各种过程可以解释从偶然到强迫性药物使用的进展，潜在的发展药物成瘾。其中两个，加速刺激-反应（S-R）习惯学习和增强分配的动机价值，以激励者，可以介导通过神经适应与持久致敏精神兴奋剂药物，即增加多巴胺能神经传递在纹状体。在这里，我们测试的假设，这两个过程，这往往被认为是相互排斥的替代品，存在于安非他明致敏大鼠。安非他明致敏大鼠表现出增加响应的食物下的随机比例的强化时间表，表明增加的激励动机价值的食物。此外，在随机间隔强化时间表下的饱腹感特异性贬值实验表明，苯丙胺致敏的动物表现出S-R习惯的加速发展。这些数据表明，在安非他明致敏大鼠中，习惯的形成和动机价值都得到了增强，并表明任务要求决定了哪种行为改变最突出地表达。(c)2007年Elsevier B. V.和ECNP。All rights reserved.
Various processes might explain the progression from casual to compulsive drug use underlying the development of drug addiction. Two of these, accelerated stimulus-response (S-R) habit learning and augmented assignment of motivational value to reinforcers, could be mediated via neuroadaptations associated with long-lasting sensitization to psychostimulant drugs, i.e. augmented dopaminergic neurotransmission in the striatum. Here, we tested the hypothesis that both processes, which are often regarded as mutually exclusive alternatives, are present in amphetamine-sensitized rats. Amphetamine-sensitized rats showed increased responding for food under a random ratio schedule of reinforcement, indicating increased incentive motivational value of food. In addition, satiety-specific devaluation experiments under a random interval schedule of reinforcement showed that amphetamine- sensitized animals exhibit accelerated development of S-R habits. These data show that both habit formation and motivational value of reinforcers are augmented in amphetamine-sensitized rats, and suggest that the task demands determine which behavioral alteration is most prominently expressed. (c) 2007 Elsevier B.V. and ECNP. All rights reserved.