Association of adult body mass index and height with anxiety, depression, and suicide in the general population
Association of adult body mass index and height with anxiety, depression, and suicide in the general population
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DOI：
10.1093/aje/kwm280
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发表时间：
2008-01-15
影响因子：
5
通讯作者：
Gunnell, David
中科院分区：
文献类型：
--
作者：
Bjerkeset, Ottar;Romundstad, Pal;Gunnell, David
一个包含74332名男性和女性的前瞻性队列被用于研究体重指数和身高与自杀、焦虑和抑郁的关联。参加北特伦德拉格健康研究（挪威，1984 - 1986年）（HUNT1）的参与者年龄在20岁及以上，并随访至2002年12月31日。1995 - 1997年使用医院焦虑和抑郁量表（HADS）对焦虑和抑郁进行测量。共有183例自杀事件。在男性和女性中，基线（1984 - 1986年）时的自杀风险随着体重指数的增加而降低。在控制了一系列心理、社会和生活方式因素的模型中，体重指数每增加一个标准差的风险比为0.82（95%置信区间：0.68，0.98）。相反，在有HADS测量值的参与者子集（n = 44396）中，基线（1984 - 1986年）时的体重指数与抑郁呈正相关。在完全调整的模型中，体重指数每增加一个标准差的抑郁比值比（HADS - D：≥8）为1.11（95%置信区间：1.07，1.15）。在完全调整的模型中，身高与自杀或抑郁的发生率没有关联。体重指数升高与男性和女性患抑郁的风险增加但自杀风险降低有关。这些不同关联背后的机制需要阐明。
A prospective cohort of 74,332 men and women was used to investigate the association of body mass index and height with suicide, anxiety, and depression. Participants in the Nord-Trondelag Health Study (Norway, 1984-1986) (HUNT 1) were aged 20 years or more and followed up until December 31, 2002. Anxiety and depression were measured with the Hospital Anxiety and Depression Rating Scale (HADS) in 1995-1997. There were 183 suicides. Suicide risk decreased with increasing body mass index at baseline (1984-1986) in men and women. In models controlling for a range of psychological, social, and lifestyle factors, the hazard ratio per standard deviation increase in body mass index was 0.82 (95% confidence interval: 0.68, 0.98). In contrast, in the subset of participants (n = 44,396) with HADS measures, body mass index at baseline (1984-1986) was positively associated with depression. In fully adjusted models, the odds ratio for depression per standard deviation increase in body mass index (HADS-D: >= 8) was 1.11 (95% confidence interval: 1.07, 1.15). In fully adjusted models, there was no association of height with the incidence of suicide or depression. Raised body mass index is associated with an increased risk of depression but reduced risk of suicide in men and women. The mechanisms underlying these different associations require clarification.