Inhibition of Nucleoside Transport
Inhibition of Nucleoside Transport
复制标题
核苷运输的抑制
DOI：
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
C. Cass
中科院分区：
文献类型：
--
作者：
A. Paterson;E. Jakobs;E. Harley;N. Fu;M. Robins;C. Cass
在许多类型的动物细胞中，核苷分子穿过质膜的运动是一种特异性的转运蛋白介导的过程[1，2]。从核苷通量的动力学性质已经认识到核苷转运机制的存在，但是质膜的核苷转运元件尚未可视化或分离，并且它们的性质仅被间接地研究。核苷转运的强效、紧密结合的抑制剂硝基苄硫代肌苷（NBMPR）1一直是转运蛋白功能和生物学的有价值的探针，例如，能够定量细胞上的转运蛋白元件[3]，并提供了从质膜制备物中分离转运蛋白元件的方法[4]。本章讨论了NBMPR、N6-硝基苄基脱氧腺苷及其某些同类物和冠状血管扩张剂地拉卓的核苷转运抑制特性。
In many types of animal cells, the movement of nucleoside molecules across the plasma membrane is a specific, transporter-mediated process [1, 2]. The existence of the nucleoside transport mechanism has been recognized from the kinetic properties of nucleoside fluxes, but nucleoside transporter elements of the plasma membrane have not yet been visualized or isolated, and their properties have only been studied indirectly. The potent, tightly bound inhibitor of nucleoside transport, nitrobenzylthioinosine (NBMPR),1 has been a valuable probe of transporter function and biology, enabling, for example, quantitation of transporter elements on cells [3] and providing an approach to their isolation from plasma membrane preparations [4]. This chapter discusses the nucleoside transport-inhibitory properties of NBMPR, N6-nitrobenzyldeoxyadenosine, and certain of their congeners, and of dilazep, a coronary vasodilator.
质膜囊泡猝灭流技术：乙酰胆碱受体介导的跨膜离子流。
影响因子：
2.9
作者：
Cash,DJ;Hess,GP
通讯作者：
Hess,GP