Treatment of persistent knee effusions with intra-articular radioactive gold.
Treatment of persistent knee effusions with intra-articular radioactive gold.
复制标题
关节内放射性金治疗持续性膝关节积液。
DOI：
10.3138/9781442631649-037
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发表时间：
1975
影响因子：
14.6
通讯作者：
J. Topp
中科院分区：
文献类型：
--
作者：
B. Ansell;A. Crook;J. R. Mallard;E. Bywaters;J. Topp
共有112例慢性膝关节积液患者对通常的保守治疗方法无反应，采用放射性金关节内注射治疗，随访6个月至5年。研究中的大多数患者患有类风湿性关节炎，但其他患者患有强直性脊柱炎、银屑病关节炎、间歇性关节积液和未确诊的滑膜炎。6个月后，81%的人表现出改善。这一数字在1年和2年时降至约70%，3年和4年时降至60%，5年时降至50%。在间歇性关节积液患者中观察到了更有益的结果。12例滑膜囊肿和/或破裂的患者改善。滑膜较薄且解剖学分期为I或II期的患者表现最好，但III期患者也表现良好。注射后，33%的患者出现反应性滑膜炎。不同数量的放射性物质从膝关节逃逸到局部淋巴结和全身循环。
Patients with a total of 112 chronic knee effusions unresponsive to the usual conservative methods of therapy were treated with intra-articular injections of radioactive gold and followed from 6 months to 5 years. Most patients in the study had rheumatoid arthritis but others had ankylosing spondylitis, psoriatic arthritis, intermittent hydrathrosis and undiagnosed synovitis. After 6 months 81% showed improvement. This figure diminished to approximately 70% at 1 and 2 years, 60% at 3 and 4 years and 50% at 5 years. The mose beneficial results were seen in patients with intermittent hydrarthrosis. Twelve patients with a synovial cyst and/or rupture improved. Patients with thin synovia and anatomic stage I or II disease did best, but those with stage III disease also did well. After the injection 33% of the patients had a reactive synovitis. A variable amount of radioactive material escaped from the knee to the regional lymph nodes and general circulation.