Analysis of 12 GWAS-Linked Loci With Parkinson's Disease in the Chinese Han Population.
Analysis of 12 GWAS-Linked Loci With Parkinson's Disease in the Chinese Han Population.
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中国汉族人群帕金森病12个GWAS连锁位点分析
DOI：
10.3389/fneur.2021.623913
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发表时间：
2021
影响因子：
3.4
通讯作者：
Xu Y
中科院分区：
文献类型：
--
作者：
Fan L;Shi C;Hu X;Zhang Z;Zheng H;Luo H;Fan Y;Zhang S;Hu Z;Yang J;Mao C;Xu Y
A recent large-scale European-originated genome-wide association study identified 38 novel independent risk signals in 37 loci for Parkinson's disease (PD). However, whether these new loci are associated with PD in Asian populations remains elusive. The present study aimed to explore the relationship between the 12 most relevant loci with larger absolute values for these new risk loci and PD in the Chinese Han population. We performed a case-control study including 527 PD patients and 435 healthy controls. In the allele model, it was found that rs10748818/GBF1 was associated with PD in the Chinese Han population [p = 0.035, odds ratio (OR) 1.221, 95% confidence interval (CI) 1.014–1.472
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