Stem cell aging is controlled both intrinsically and extrinsically in the Drosophila ovary
Stem cell aging is controlled both intrinsically and extrinsically in the Drosophila ovary
复制标题
果蝇卵巢中的干细胞衰老受到内在和外在的控制
DOI：
10.1016/j.stem.2007.09.010
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发表时间：
2007-10-01
期刊：
影响因子：
23.9
通讯作者：
Xie, Ting
中科院分区：
文献类型：
--
作者：
Pan, Lei;Chen, Shuyi;Xie, Ting
人们普遍认为，组织衰老可能至少部分是由于干细胞数量减少、活性降低或两者兼而有之。然而，控制干细胞衰老的机制在很大程度上仍然是一个谜。在这里，我们使用果蝇卵巢生殖系干细胞(GSCs)作为模型来证明干细胞功能的年龄依赖性下降及其生态位对整体干细胞老化的贡献。随着年龄的增长，来自骨小窝的BMP信号活性显著降低，增加BMP信号可以延长GSC的寿命，促进其增殖。此外，干细胞-巢连接中与年龄相关的E-钙粘附素的下降也是干细胞老化的原因之一。最后，在GSC或其利基中过度表达有助于消除游离氧的酶--超氧化物歧化酶--可以延长GSC的寿命并增加GSC的增殖。因此，本研究表明，在果蝇卵巢中，干细胞衰老受到外在和内在的控制。
It is widely postulated that tissue aging could be, at least partially, caused by reduction of stem cell number, activity, or both. However, the mechanisms of controlling stem cell aging remain largely a mystery. Here, we use Drosophila ovarian germline stem cells (GSCs) as a model to demonstrate that age-dependent decline in the functions of stem cells and their niche contributes to overall stem cell aging. BMP signaling activity from the niche significantly decreases with age, and increasing BMP signaling can prolong GSC life span and promote their proliferation. In addition, the age-dependent E-cadherin decline in the stem cell-niche junction also contributes to stem cell aging. Finally, overexpression of SOD, an enzyme that helps eliminate free oxygen species, in either GSCs or their niche alone can prolong GSC life span and increase GSC proliferation. Therefore, this study demonstrates that stem cell aging is controlled extrinsically and intrinsically in the Drosophila ovary.