Invasion of vertebrate cells by Toxoplasma gondii.
Invasion of vertebrate cells by Toxoplasma gondii.
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弓形虫入侵脊椎动物细胞。
DOI：
10.1016/s0962-8924(00)88964-3
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发表时间：
1995
影响因子：
19
通讯作者：
Sibley,LD
中科院分区：
文献类型：
--
作者：
Sibley,LD
弓形虫主动侵入宿主细胞，而不是通过常规的吞噬作用进入。入侵是由寄生虫中基于微顺应性的运动系统提供动力，该运动系统导致宿主细胞质膜内陷以形成新的细胞内空泡。这种空泡抵抗与宿主细胞内吞网络的融合，并为寄生虫的复制提供保护性环境。
Toxoplasma gondii actively invades its host cell rather than entering by conventional phagocytosis. Invasion is powered by a micro filament-based motility system in the parasite that leads to invagination of the host cell plasma membrane to form a novel intracellular vacuole. This vacuole resists fusion with the endocytic network of the host cell and provides a protective environment for replication o f the parasite.