Human Herpesvirus 8 Infection in Children and Adults in a Population-based Study in Rural Uganda
Human Herpesvirus 8 Infection in Children and Adults in a Population-based Study in Rural Uganda
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DOI：
10.1093/infdis/jiq092
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发表时间：
2011-03-01
影响因子：
6.4
通讯作者：
Mermin, Jonathan
中科院分区：
文献类型：
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作者：
Butler, Lisa M.;Were, Willy A.;Mermin, Jonathan
方法.参与者是1383名儿童和1477名成年人从人口为基础的样本在乌干达的农村社区。用K8.1酶免疫法检测血清中HHV-8抗体。HHV-8血清阳性率从1.5-2岁儿童的16%增加到10-13岁儿童的32%（P = 50岁（P = 1名其他血清阳性儿童年龄< 14岁（P < .001））。共享食物和/或酱料盘的历史与儿童HHV-8感染轻微相关（P = .05）。在1404名年龄≥ 15岁的参与者中，性行为（如终生性伴侣数量和HIV感染）与HHV-8血清阳性之间没有相关性（P > 0.10）。我们的数据表明，HHV-8主要是通过家庭内接触在儿童期的水平传播获得的，并可能通过非性途径继续传播到成年期。
Methods. Participants were 1383 children and 1477 adults from a population-based sample in a rural community in Uganda. Serum samples were tested for HHV-8 antibodies with use of an enzyme immunoassay against K8.1.Results. HHV-8 seroprevalence increased from 16% among children aged 1.5-2 years to 32% among children aged 10-13 years (P = 50 years (P = 1 other seropositive child aged < 14 years (P < .001). History of sharing food and/or sauce plates was marginally associated with HHV-8 infection in children (P = .05). Among 1404 participants aged >= 15 years , there was no association between correlates of sexual behavior (eg, number of lifetime sex partners and HIV infection) and HHV-8 seropositivity (P > .10).Conclusions. Our data suggest that HHV-8 is acquired primarily through horizontal transmission in childhood from intrafamilial contacts and that transmission continues into adulthood potentially through nonsexual routes.