Evolutionary plasticity of segmentation clock networks
Evolutionary plasticity of segmentation clock networks
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DOI：
10.1242/dev.063834
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发表时间：
2011-07-01
期刊：
影响因子：
4.6
通讯作者：
Pourquie, Olivier
中科院分区：
文献类型：
--
作者：
Krol, Aurelie J.;Roellig, Daniela;Pourquie, Olivier
脊柱是一种保守的解剖学结构，定义了脊椎动物门。脊柱的周期性或节段性模式是在发育早期确立的，当时脊椎前体，即体节，是由发育前的中胚层(PSM)有节奏地产生的。这种节律活动由一个分段时钟控制，该时钟与PSM中周期基因的周期性转录有关。对小鼠、鸡和斑马鱼PSM振荡转录本的比较发现，40到100个循环基因组成的网络主要参与Notch、Wnt和Fgf信号通路。然而，尽管这种保守的信号振荡，单个循环基因的同一性在这三个物种之间大多不同，这表明片段网络具有令人惊讶的进化可塑性。
The vertebral column is a conserved anatomical structure that defines the vertebrate phylum. The periodic or segmental pattern of the vertebral column is established early in development when the vertebral precursors, the somites, are rhythmically produced from presomitic mesoderm (PSM). This rhythmic activity is controlled by a segmentation clock that is associated with the periodic transcription of cyclic genes in the PSM. Comparison of the mouse, chicken and zebrafish PSM oscillatory transcriptomes revealed networks of 40 to 100 cyclic genes mostly involved in Notch, Wnt and FGF signaling pathways. However, despite this conserved signaling oscillation, the identity of individual cyclic genes mostly differed between the three species, indicating a surprising evolutionary plasticity of the segmentation networks.