Volume-dependent effect of supervised exercise training on fatty liver and visceral adiposity index in subjects with type 2 diabetes The Italian Diabetes Exercise Study (IDES)
Volume-dependent effect of supervised exercise training on fatty liver and visceral adiposity index in subjects with type 2 diabetes The Italian Diabetes Exercise Study (IDES)
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DOI：
10.1016/j.diabres.2015.05.033
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发表时间：
2015-08-01
影响因子：
5.1
通讯作者：
Pugliese, Giuseppe
中科院分区：
文献类型：
--
作者：
Balducci, Stefano;Cardelli, Patrizia;Pugliese, Giuseppe
目的：本研究评估了监督运动训练对2型糖尿病患者肝酶和非酒精性脂肪肝（NAFLD）两项替代指标的影响。方法：22名糖尿病门诊患者按中心、年龄和治疗方式随机接受每周两次的监督有氧和阻力训练加结构化运动咨询（运动组，EXE; n = 303）与单独咨询（对照组，CON; n = 303）12个月。EXE参与者被进一步随机分配到低到中等（n = 142）或中等到高（n = 161）强度训练的相等的能量成本。基线和研究结束时的肝酶，脂肪肝指数（FLI）和内脏肥胖指数（VAI）的水平是gathered.Results：酶水平没有变化，而FLI和VAI显着下降EXE，但CON参与者。体力活动（PA）量是FLI和VAI降低的独立预测因子，其程度从PA量的第1个五分位数增加到第4个五分位数，以及健身参数的基线到研究结束变化。LI与HI训练效果的差异可以忽略不计。结论：来自2型糖尿病受试者这一大队列的数据表明，FLI和VAI减少与监督的训练量依赖性的方式。(C)2015爱思唯尔爱尔兰有限公司版权所有。
Aims: This study evaluated the effect of supervised exercise training on liver enzymes and two surrogate measures of non-alcoholic fatty liver disease (NAFLD) in subjects with type 2 diabetes.Methods: Sedentary patients from 22 outpatient diabetes clinics were randomized by center, age and treatment to twice-a-week supervised aerobic and resistance training plus structured exercise counseling (exercise group, EXE; n = 303) versus counseling alone (control group, CON; n = 303) for 12 months. EXE participants were further randomized to low-to-moderate (n = 142) or moderate-to-high (n = 161) intensity training of equal energy cost. Baseline and end-of-study levels of liver enzymes, fatty liver index (FLI) and visceral adiposity index (VAI) were obtained.Results: Enzyme levels did not change, whereas FLI and VAI decreased significantly in EXE, but not CON participants. Physical activity (PA) volume was an independent predictor of both FLI and VAI reductions, the extent of which increased from the 1st to the 4th quintile of PA volume and baseline to end-of-study changes in fitness parameters. Differences in the effect of LI versus HI training were negligible.Conclusions: Data from this large cohort of subjects with type 2 diabetes indicate that FLI and VAI decrease with supervised training in a volume-dependent manner. (C) 2015 Elsevier Ireland Ltd. All rights reserved.