Electrospinning of PVA-carboxymethyl cellulose nanofibers for flufenamic acid drug delivery
Electrospinning of PVA-carboxymethyl cellulose nanofibers for flufenamic acid drug delivery
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DOI：
10.1016/j.ijbiomac.2020.09.129
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发表时间：
2020-11-15
影响因子：
8.2
通讯作者：
Ghoreishi, Seyyed Mohammad
中科院分区：
文献类型：
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作者：
Allafchian, Alireza;Hosseini, Hassan;Ghoreishi, Seyyed Mohammad
纳米技术的一个突出的医学应用是药物输送。本文以羧甲基纤维素（CMC）和聚乙烯醇（PVA）为原料，制备了氟芬那酸（FFA）负载CMC/PVA水基纳米纤维。对于静电纺丝，考虑具有90/10、80/20、70/30、60/40和50/50比率的CMC/PVA溶液。研究了两种在静电纺丝过程中将游离脂肪酸负载到纳米纤维上的集成方法。利用SEM、AFM、荧光显微镜和FT-IR等表征技术对所制备的纳米纤维进行了表征，结果表明FFA在整个样品中分布均匀。所得纳米纤维形成的直径范围为176-285 nm，并在PBS缓冲溶液中表现出5 h的降解时间。获得了样品的载药量标准图。使用透析管法检查药物释放模式。紫外-可见光谱显示CMC/PVA/FFA纳米纤维中的药物释放行为具有时间依赖性，在第一个20 min内发生急剧释放。然而，使用交联剂（EDC）实现了10 h的延长释放时间。(C)2020爱思唯尔B. V.保留所有权利。
A prominent medical application of nanotechnology is represented in drug delivery. In this work, carboxymethyl cellulose (CMC) and poly(vinyl alcohol) (PVA) were used for producing CMC/PVA aqueous-based nanofibers loaded with flufenamic acid (FFA) as a drug containing amine groups. The CMC/PVA solutions with 90/10, 80/20, 70/30, 60/40 and 50/50 ratios were considered for electrospinning. Two integration methods were studied for loading FFA on the nanofibers during the electrospinning process. The characterization techniques of SEM, AFM, fluorescence microscopy and FT-IR spectroscopy were used to study the produced nanofibers, indicating a uniform distribution of FFA throughout the samples. The resulting nanofibers were formed in a diameter range of 176-285 nm and exhibited a 5 h degradation time in the PBS buffer solution. A standard diagram of drug loading was obtained for the samples. The drug release pattern was examined using a dialysis tube method. UV-visible spectroscopy revealed a time-dependent drug release behavior in CMC/PVA/FFA nanofibers where a sharp release occurred over the first 20 min. However, a prolonged release time of 10 h was achieved using a cross-linker (EDC). (C) 2020 Elsevier B.V. All rights reserved.