Comprehensive Assessment of Alcohol Consumption in People Living with HIV (PLWH): The New Orleans Alcohol Use in HIV Study
Comprehensive Assessment of Alcohol Consumption in People Living with HIV (PLWH): The New Orleans Alcohol Use in HIV Study
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DOI：
10.1111/acer.14336
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发表时间：
2020-05-22
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影响因子：
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通讯作者：
Molina, Patricia E.
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作者：
Ferguson, Tekeda F.;Theall, Katherine P.;Molina, Patricia E.
HIV感染者（PLWH）饮酒频率高，需要仔细评估和筛查，以更好地了解其对HIV疾病进展和合并症发展的影响。由于用于测量酒精使用的工具的局限性，健康后果的联系是不完全understood.Methods我们完成了一个横断面分析，以检查使用多种酒精评估工具和他们的相关性和一致性在一个队列的PLWH（N = 365）参加新奥尔良酒精使用艾滋病毒（NOAH）研究的饮酒率。使用酒精使用障碍识别测试（AUDIT）、时间轴追踪（TLFB）日历、终生饮酒史、酒精和药物成瘾严重程度指数和血液磷脂酰乙醇（PEth）水平评估酒精使用情况。斯皮尔曼的相关性进行了估计，连续测量的酒精消费; Wilcoxon秩和检验被用来比较的手段;和Logistic回归估计的赔率酒精使用的人口统计学特征。结果自我报告的当前酒精使用的变化从58.9到73.7%，取决于评估。所有自我报告的酒精测量结果均显示与生物标志物PEth具有统计学显著相关性。与TLFB克数的相关性最高（r = 0.67，p < 0.001）。使用TLFB，73.7%的队列报告在过去30天内使用酒精，61.6%的PEth值为阳性。达到TLFB > 3（女性）或>4（男性）饮酒/天或>7（女性）或>14（男性）饮酒/周的危险饮酒者的患病率为49.0%。40.3%的人报告了中度风险饮酒（定义为AUDIT评分>= 8），高风险饮酒者/可能的AUD（AUDIT评分>= 16）符合17.0%的cohol.Conclusions我们的研究结果证明了酒精使用综合评估的重要性，包括通过由训练有素的工作人员管理的多种评估工具进行自我报告，以及添加生物标志物以改进将受试者分类为不同饮酒类别。
Background High frequency of alcohol use among people living with HIV (PLWH) warrants careful assessment and screening to better understand its impact on HIV disease progression and development of comorbidities. Due to the limitations of the tools used to measure alcohol use, the links to health consequences are not fully understood.Methods We completed a cross-sectional analysis to examine the prevalence of alcohol consumption using multiple alcohol assessment tools and their correlation and consistency in a cohort of PLWH (N = 365) enrolled in the New Orleans Alcohol Use in HIV (NOAH) Study. Alcohol use was assessed with the Alcohol Use Disorders Identification Test (AUDIT), timeline followback (TLFB) Calendar, lifetime drinking history, Alcohol and Drug Addiction Severity Index, and blood levels of phosphatidylethanol (PEth). Spearman's correlations were estimated for continuous measures of alcohol consumption; Wilcoxon rank-sum tests were used to compare means; and logistic regression was used to estimate odds of alcohol use by demographic characteristics.Results Self-report of current alcohol use varied from 58.9 to 73.7% depending on the assessment. All the self-reported alcohol measures showed statistically significant correlations with the biological marker PEth. The highest correlation was with TLFB grams (r = 0.67, p < 0.001). Using TLFB, 73.7% of the cohort reported using alcohol in the last 30 days, and 61.6% had a positive PEth value. The prevalence of risky drinkers, meeting the TLFB > 3 (women) or >4 (men) drinks/day or>7 (women) or>14 (men) drinks/week, was 49.0%. Medium-risk drinking defined as an AUDIT score >= 8 was reported in 40.3%, and high-risk drinkers/probable AUD (AUDIT score >= 16) was met by 17.0% of the cohort.Conclusions Our results demonstrate the importance of comprehensive assessments for alcohol use, including self-report via multiple assessment tools administered by trained staff, as well as the addition of biomarkers for improved classification of subjects into different drinking categories.