Emergence of daptomycin non-susceptibility in colonizing vancomycin-resistant Enterococcus faecium isolates during daptomycin therapy
Emergence of daptomycin non-susceptibility in colonizing vancomycin-resistant Enterococcus faecium isolates during daptomycin therapy
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DOI：
10.1016/j.ijmm.2015.09.005
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发表时间：
2015-12-01
影响因子：
4.1
通讯作者：
Rohde, Holger
中科院分区：
文献类型：
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作者：
Lellek, Heinrich;Franke, Gefion C.;Rohde, Holger
耐万古霉素肠球菌(VRE)感染在高危人群中具有重要意义，达托霉素是一种杀菌抗生素，用于治疗这些患者的多药耐药VRE。达托霉素治疗过程中出现的非敏感侵袭性VRE是临床上的一大难题。在这里，测试的假设是，全身达托霉素治疗也诱导了达托霉素不敏感(DNS-)分离株出现在定植的VRE人群中。对从直肠拭子中回收的11对万古霉素耐药屎肠球菌进行分析。所有初始分离株在粪肠球菌野生型MIC分布中均显示达托霉素MIC
Infections due to vancomycin-resistant enterococci (VRE) are of significant importance in high-risk populations, and daptomycin is a bactericidal antibiotic to treat multidrug-resistant VRE in these patients. The emergence of daptomycin non-susceptibility invasive VRE during daptomycin therapy is a major clinical issue. Here the hypothesis was tested that systemic daptomycin therapy also induces the emergence of daptomycin non-susceptible (DNS-) isolates in colonizing VRE populations. 11 vancomycin-resistant Enterococcus faecium strain pairs recovered from rectal swabs were available for analysis. All initial isolates exhibited daptomycin MICs within the wild type MIC distribution of E. faecium (MIC