Can One Concurrently Record Electrical Spikes from Every Neuron in a Mammalian Brain?
Can One Concurrently Record Electrical Spikes from Every Neuron in a Mammalian Brain?
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DOI：
10.1016/j.neuron.2019.08.011
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发表时间：
2019-09-25
期刊：
影响因子：
16.2
通讯作者：
Harris, Timothy D.
中科院分区：
文献类型：
--
作者：
Kleinfeld, David;Luan, Lan;Harris, Timothy D.
测量神经元放电反应的经典方法是使用金属电极记录细胞外电位。从60多年前的单一记录站点开始，这项技术现在扩展到越来越多的站点和密度。我们认为，基于现有材料的机械和电学性质、信噪比的估计、关于大脑细胞外空间的假设以及对电子接口产生的热的估计，应该可以制造刚性电极来同时记录皮质地幔中的几乎每个神经元。这将涉及到用现有的但非传统的材料和程序进行制造。我们进一步强调改进柔性电极材料的必要性，将其作为记录运动动物脑干和脊髓神经元的重要进步。
The classic approach to measure the spiking response of neurons involves the use of metal electrodes to record extracellular potentials. Starting over 60 years ago with a single recording site, this technology now extends to ever larger numbers and densities of sites. We argue, based on the mechanical and electrical properties of existing materials, estimates of signal-to-noise ratios, assumptions regarding extracellular space in the brain, and estimates of heat generation by the electronic interface, that it should be possible to fabricate rigid electrodes to concurrently record from essentially every neuron in the cortical mantle. This will involve fabrication with existing yet nontraditional materials and procedures. We further emphasize the need to advance materials for improved flexible electrodes as an essential advance to record from neurons in brainstem and spinal cord in moving animals.