Nerve growth factor and prostaglandins in the urine of female patients with overactive bladder
Nerve growth factor and prostaglandins in the urine of female patients with overactive bladder
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DOI：
10.1016/s0022-5347(05)00992-4
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发表时间：
2006-05-01
影响因子：
6.6
通讯作者：
Hwang, TK
中科院分区：
文献类型：
--
作者：
Kim, JC;Park, EY;Hwang, TK
目的：膀胱内的NGF和pg可受膀胱病理变化的影响，这些变化可在尿液中检测到。我们研究了OAB女性尿NGF和pg的变化。材料和方法：研究组包括65名OAB女性和20名无膀胱症状的女性作为对照组。评估包括患者病史、尿液分析、排尿日记和尿动力学研究。采集尿液样本。采用酶联免疫吸附法测定NGF、PGE(2)、PGF（2 α）、PGI(2)，并进行组间比较。此外，我们还研究了OAB患者尿NGF和PG以及尿动力学参数之间的相关性。结果：与对照组相比，OAB患者尿NGF、PGE(2)和PGF（2 α）显著升高(p
Purpose: NGF and PGs in the bladder can be affected by pathological changes in the bladder and these changes can be detected in urine. We investigated changes in urinary NGF and PGs in women with OAB.Materials and Methods: The study groups included 65 women with OAB and 20 without bladder symptoms who served as controls. Evaluation included patient history, urinalysis, a voiding diary and urodynamic studies. Urine samples were collected. NGF, PGE(2), PGF(2 alpha) and PGI(2) were measured using enzyme-linked immunosorbent assay and compared between the groups. In addition, correlations between urinary NGF and PG, and urodynamic parameters in patients with OAB were examined.Results: Urinary NGF, PGE(2) and PGF(2 alpha) were significantly increased in patients with OAB compared with controls (p