Diversity Matters: A Revised Guide to Myelination.
Diversity Matters: A Revised Guide to Myelination.
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DOI：
10.1016/j.tcb.2015.09.002
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发表时间：
2016-02
影响因子：
19
通讯作者：
Arlotta P
中科院分区：
文献类型：
--
作者：
Tomassy GS;Dershowitz LB;Arlotta P
The evolutionary success of the vertebrate nervous system is largely due to a unique structural feature - the myelin sheath, a fatty envelope that surrounds the axons of neurons. By increasing the speed by which electrical signals travel along axons, myelin facilitates neuronal communication between distant regions of the nervous system. Here, we review the cellular and molecular mechanisms that regulate the development of myelin as well as its homeostasis in adulthood. We discuss how finely tuned neuron-oligodendrocyte interactions are central to myelin formation during development and in the adult and how these interactions can have profound implications for the plasticity of the adult brain. We also speculate how the functional diversity of both neurons and oligodendrocytes may impact the myelination process in both health and disease.
