Benzidine mechanistic data and risk assessment: species- and organ-specific metabolic activation.
Benzidine mechanistic data and risk assessment: species- and organ-specific metabolic activation.
复制标题
DOI：
10.1016/0163-7258(96)00064-2
复制
发表时间：
1996
影响因子：
13.5
通讯作者：
J. Whysner;Lynne Verna;Gary M. Williams
中科院分区：
文献类型：
--
作者：
J. Whysner;Lynne Verna;Gary M. Williams
芳香胺联苯胺（BZ）在小鼠、大鼠和仓鼠体内产生多种肿瘤，包括肝肿瘤。BZ在啮齿动物肝脏中形成DNA加合物，在大多数遗传毒性试验中呈阳性。只有在犬类和职业暴露的人类中才会产生膀胱肿瘤，这可能与乙酰化导致的肝脏解毒速度缓慢有关，这使得BZ或其代谢产物在尿液中被激活。尽管存在这些差异，基于小鼠肝脏肿瘤的人类风险评估，大致可以预测工业暴露的人类膀胱肿瘤的发生率。
The aromatic amine benzidine (BZ) has produced various tumors, including liver tumors, in mice, rats and hamsters. BZ forms DNA adducts in rodent liver, and it is positive in most genotoxicity tests. Only bladder tumors are produced in dogs and in humans who have been occupationally exposed, possibly related to the slow rate of liver detoxification by acetylation, allowing activation of BZ or its metabolites in urine. Despite these differences, risk assessment for humans, based on liver tumors in mice, was approximately predictive of the incidence of bladder tumors observed in industrially exposed humans.