Risk of cancer after the diagnosis of Parkinson's disease: A historical cohort study
Risk of cancer after the diagnosis of Parkinson's disease: A historical cohort study
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DOI：
10.1002/mds.20401
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发表时间：
2005-06-01
影响因子：
8.6
通讯作者：
Rocca, WA
中科院分区：
文献类型：
--
作者：
Elbaz, A;Peterson, BJ;Rocca, WA
我们通过一项历史队列研究调查了帕金森病（PD）诊断后的癌症风险。我们使用罗切斯特流行病学项目的医疗记录链接系统来识别明尼苏达州奥姆斯特德县从1976年到1995年的所有PD病例。PD患者按年龄（1岁）和性别与来自同一人群的参考受试者相匹配。对196名患者和185名对照受试者，我们通过从诊断日期（或索引日期）到死亡、随访缺失或研究结束之间的病历提取来确定癌症的发病率。患者发生癌症的风险高于对照组（相对危险度[RR] = 1.64； 95%可信区间[CI] = 1.15-2.35; P = 0.007）。调整吸烟因素后，RR无明显变化。非黑色素瘤皮肤癌的风险显著增加（RR = 1.76, 95% CI = 1.07-2.89; P = 0.03），但其他更严重类型的癌症没有增加风险；因此，我们不能排除监测偏差的发生。在PD患者中，癌症风险与接受左旋多巴的累积剂量或其他PD药物的使用没有关系。(c) 2005年运动障碍协会。
We investigated the risk of cancer after the diagnosis of Parkinson's disease (PD) through a historical cohort study. We used the medical records-linkage system of the Rochester Epidemiology Project to identify all incident cases of PD in Olmsted County, Minnesota from 1976 through 1995.Patients with PD were matched by age (1 year) and gender to referent subjects from the same population. For 196 patients and 185 referent subjects, we ascertained the incidence of cancer through medical records abstraction between the date of diagnosis (or index date) and death, loss to follow-up, or end of study. The risk of cancer was higher among patients than in referent subjects (relative risk [RR] = 1.64; 95% confidence interval [CI] = 1.15-2.35; P = 0.007). The RR did not change noticeably after adjustment for smoking. The increased risk was significant for nonmelanoma skin cancer (RR = 1.76 95% CI = 1.07-2.89; P = 0.03), but not for other more severe types of cancer; therefore, we cannot exclude the occurrence of a surveillance bias. Among PD patients, there was no relation between the risk of cancer and the cumulative dose of levodopa received or the use of other PD medications. (c) 2005 Movement Disorder Society.