Unraveling the mission of FcεRI on antigen-presenting cells
Unraveling the mission of FcεRI on antigen-presenting cells
复制标题
DOI：
10.1067/mai.2003.2
复制
发表时间：
2003-01-01
影响因子：
14.2
通讯作者：
Bieber, T
中科院分区：
文献类型：
--
作者：
Novak, N;Kraft, S;Bieber, T
十年前，在表皮朗格汉斯细胞上发现了IgE的高亲和力受体（FcepsilonRI），证明了FcepsilonRI仅在过敏反应的效应细胞上表达的教条的终结。从那时起，这种受体对抗原呈递细胞（APC）的功能意义一直是一个激烈的研究工作领域。科学家们专注于更好地了解FcepsilonRI对人类免疫系统中APC的分子结构，调节和作用。深入了解与IgE和过敏原连接FcepsilonRI激活APC相关的细胞事件可能为过敏性疾病的病理生理学和未来诊断和治疗策略的设计提供新的方面的基础。这篇综述是专门为10周年的发现FcepsilonRI的APC和描述了在这一领域的研究的众多领域。
A decade ago, the discovery of the high-affinity receptor for IgE (FcepsilonRI) on epidermal Langerhans cells documented the end of the dogma that FcepsilonRI is only expressed on effector cells of anaphylaxis. Since then, the functional significance of this receptor on antigen-presenting cells (APCs) has been an area of intense research work. Scientists have focused on a better understanding of the molecular structure, regulation, and role of FcepsilonRI on APCs in the human immune system. Insights into the cellular events linked to the activation of APCs on ligation of FcepsilonRI by IgE and allergens might provide the basis for new aspects in the pathophysiology of allergic diseases and the design of future diagnostic and therapeutic strategies. This review is dedicated to the 10th anniversary of the discovery of FcepsilonRI on APCs and describes the numerous areas of research in this field.