Promiscuity of autoimmune responses to MBP after stroke.
Promiscuity of autoimmune responses to MBP after stroke.
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DOI：
10.1016/j.jneuroim.2015.05.024
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发表时间：
2015-08-15
影响因子：
3.3
通讯作者：
Becker K
中科院分区：
文献类型：
--
作者：
Zierath D;Kunze A;Fecteau L;Becker K
In this study we examined Th1 and Th17 immune responses to rat myelin basic protein (MBP), bovine MBP, human MBP, MBP 68-86, MBP 63-81 and ovalbumin in Lewis rats to determine which MBP antigen is recognized following ischemic brain injury. Responses were compared to animals immunized to rat MBP. Data show that immune responses following immunization with rat MBP are promiscuous with cross reaction to MBP from other species. After stroke, few animals develop Th1 or Th17 responses to MBP, but when those responses occur, especially Th1 responses to rat MBP in brain, they are predictive of worse stroke outcome.
