Thromboembolic Events in Malignant Pleural Mesothelioma
Thromboembolic Events in Malignant Pleural Mesothelioma
复制标题
恶性胸膜间皮瘤的血栓栓塞事件
DOI：
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发表时间：
2016
期刊：
影响因子：
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通讯作者：
G. Fındık
中科院分区：
文献类型：
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作者：
D. Koksal;O. Safak;A. Ozcan;Y. Ağaçkıran;H. Erturk;G. Fındık
目的：恶性胸膜间皮瘤（MPM）增加血栓栓塞事件（tee）的风险。在这项回顾性研究中，我们旨在确定tee在MPM中的发病率，并探讨其与血小板增多、疾病分期和肿瘤组织病理学的关系。方法：本研究纳入2008年1月至2014年6月间经组织病理学诊断为MPM的178例患者。结果：患者平均年龄58.7±11.8岁，中位随访时间8个月。血小板增多71例（39.9%）（bb0 350 × 103/mL）。共发现14例tee(7.9%): 6例（3.4%）肺血栓栓塞，6例（3.4%）深静脉血栓形成，2例（1.1%）心肌梗死。其中5例（2.8%）发生在MPM诊断之前，1例（0.6%）与MPM同时发生，8例（4.5%）发生在MPM诊断之后。血小板增多（P = 0.51）、疾病分期（P = 0.14）和组织病理学（P = 0.38）对血栓栓塞事件发生率的影响无统计学差异。结论：tee发生率为7.9%。存在血小板增多症、疾病分期和组织病理学不影响tee的发生率。
Aim: Malignant pleural mesothelioma (MPM) increases the risk of thromboembolic events (TEEs). In this retrospective study, we aimed to determine the rate of TEEs in MPM and investigate its relationship with the presence of thrombocytosis, the disease stage, and the tumor histopathology. Methods: The study included 178 patients who were histopathologically diagnosed as MPM between the years January 2008 and June 2014. Results: The mean age was 58.7 ± 11.8 years, and the median follow-up time was 8 months. Seventy-one patients (39.9%) had thrombocytosis (>350 × 103/mL). In total, 14 (7.9%) TEEs were identified: 6 (3.4%) pulmonary thromboembolism, 6 (3.4%) deep venous thrombosis, and 2 (1.1%) myocardial infarctions. Although 5 (2.8%) of the TEEs preceded the diagnosis of MPM, 1 (0.6%) occurred simultaneously with the diagnosis of MPM and 8 (4.5%) followed the diagnosis of MPM. Thromboembolic event rates were not statistically different based on the presence of thrombocytosis (P = .51), disease stage (P = .14), and histopathology (P = .38). Conclusion: The rate of TEEs was 7.9%. Presence of thrombocytosis, disease stage, and histopathology did not affect the incidence of TEEs.
影响因子：
7.5
作者：
Khorana, Alok A.;McCrae, Keith R.
通讯作者：
McCrae, Keith R.
影响因子：
20.3
作者：
Khorana, Alok A.;Kuderer, Nicole M.;Francis, Charles W.
通讯作者：
Francis, Charles W.