Neurocognitive Impairments and Their Improvement Following Exercise and Dietary Interventions in Older Patients With Heart Failure With Preserved Ejection Fraction.
Neurocognitive Impairments and Their Improvement Following Exercise and Dietary Interventions in Older Patients With Heart Failure With Preserved Ejection Fraction.
复制标题
射血分数保留的老年心力衰竭患者运动和饮食干预后的神经认知障碍及其改善。
DOI：
10.1161/circheartfailure.123.011134
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发表时间：
2024
期刊：
影响因子：
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通讯作者：
Hugenschmidt,ChristinaE
中科院分区：
文献类型：
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作者：
Schaich,ChristopherL;Hughes,TimothyM;Kitzman,DalaneW;Jung,Youngkyoo;Chen,Haiying;Nicklas,BarbaraJ;Houston,DeniseK;Brubaker,PeterH;Molina,AnthonyJA;Hugenschmidt,ChristinaE
射血分数保留性心力衰竭（HFpEF）目前被认为是一种与多种合并症和广泛炎症相关的全身性疾病，对大多数器官系统产生不利影响。1 HFpEF中常见的合并症，如高血压、精神障碍和血脂异常，也与全因痴呆的风险增加有关。2运动和热量限制（CR）干预，显示出改善HFpEF患者的运动能力和生活质量，似乎有助于保持肥胖老年人的大脑健康。因此，神经认知功能障碍可能是HFpEF的一个未被充分认识的特征，可能适合于已知可改善其他关键结局的生活方式干预。然而，没有研究系统地检查相对于正常人群范围的详细认知功能或评估CR和运动对HFpEF中认知功能、脑结构和脑血流量（CBF）的影响。ClinicalTrials. gov; NCT 02636439），这是一项在临床稳定肥胖HFpEF老年患者中进行的随机、单盲、单中心临床试验。4其目的是确定在20周的CR和有氧运动中加入阻力训练是否
Heart failure with preserved ejection fraction (HFpEF) is currently understood as a systemic disorder associated with multiple comorbidities and widespread inflammation that adversely affects most organ systems. 1 Comorbidities common in HFpEF such as hypertension, dysglycemia, and dyslipidemia are also individually and additively associated with greater risk for all-cause dementia. 2 Exercise and caloric restriction (CR) interventions, shown to improve exercise capacity and quality of life among patients with HFpEF, seem to help preserve brain health in older people with obesity. 3 Thus, neurocognitive dysfunction may be an underrecognized feature of HFpEF that is potentially amenable to lifestyle interventions known to improve other key outcomes. However, no studies have systematically examined detailed cognitive function relative to normative population ranges or assessed the impact of CR and exercise on cognitive function, brain structure, and cerebral blood flow (CBF) in HFpEF.We conducted an analysis ancillary to the SECRET-II trial (Study of the Effect of CR and Exercise Training in Patients with Heart Failure and a Normal Ejection Fraction; https://www. clinicaltrials. gov; NCT02636439), a randomized, single-blind, single-site clinical trial in older patients with clinically stable obese HFpEF. 4 Its objective was to determine whether the addition of resistance training to a 20-week CR and aerobic exercise