Synthesis of 1,2,4-Triazolo[4,3-a]pyridines and Related Heterocycles by Sequential Condensation and Iodine-Mediated Oxidative Cyclization
Synthesis of 1,2,4-Triazolo[4,3-a]pyridines and Related Heterocycles by Sequential Condensation and Iodine-Mediated Oxidative Cyclization
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通过顺序缩合和碘介导的氧化环化合成 1,2,4-三唑并[4,3-a]吡啶和相关杂环
DOI：
10.1002/chem.201601744
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发表时间：
2016-07-25
影响因子：
4.3
通讯作者：
Chang, Junbiao
中科院分区：
文献类型：
--
作者：
Li, Ertong;Hu, Zhiyuan;Chang, Junbiao
通过芳基肼与相应醛的缩合反应，碘介导的氧化环化反应，得到1，2，4-三唑并[4，3-a]吡啶及其相关杂环化合物。这种无过渡金属的合成方法广泛适用于各种芳香族、脂肪族和α，β-不饱和醛，并且可以方便地在克级上进行。
A facile and efficient approach to access 1,2,4-triazolo[4,3-a]pyridines and related heterocycles has been accomplished through condensation of readily available aryl hydrazines with corresponding aldehydes followed by iodine-mediated oxidative cyclization. This transition-metal-free synthetic process is broadly applicable to a variety of aromatic, aliphatic, and alpha,beta-unsaturated aldehydes, and can be conveniently conducted on the gram scale.