Cross-sectional association of physical activity and periodontal antibodies.
Cross-sectional association of physical activity and periodontal antibodies.
复制标题
DOI：
10.1002/jper.17-0709
复制
发表时间：
2018-12
影响因子：
4.3
通讯作者：
Merchant, Anwar T.
中科院分区：
文献类型：
--
作者：
Anderson, A. Paige;Park, Yong-Moon;Shrestha, Deepika;Zhang, Jiajia;Liu, Jihong;Merchant, Anwar T.
本研究的目的是评估体力活动与血清抗牙周微生物IgG抗体之间的横断面关联。研究人群包括随机选择的5,611名参加国家健康与营养调查（NHANES） III（1988年至1994年）的美国成年人，他们年龄在40岁及以上，对19种口腔微生物具有完整的IgG抗体数据。我们使用聚类分析将19个抗体滴度分为4个相互排斥的组，称为“橙色-红色”，“红色-绿色”，“黄色-橙色”和“橙色-蓝色”，并通过将四组的抗体滴度z分数相加来计算聚类分数。身体活动的评估是基于上个月进行的身体活动的频率和强度。参与者被分为三类：充分运动、不充分运动和不运动。结果为IgG聚类得分，以体力活动为预测因子。多变量模型校正了年龄、性别、种族、吸烟状况、腰围、教育程度、贫困收入比、酒精和糖尿病。在调整后的模型中，体力活动与橙蓝色集群（E. nodatum, a . naeslundii）中的抗体呈正相关，这一集群与健康的牙周状态相关。模型3的聚类得分平均差异为15.2 (95% CI−1.0,31.4)，模型4中充分运动组与不运动组的聚类得分平均差异为7.0 （95% CI−8.3,22.3）。反映口腔健康状况良好的牙周微生物抗体滴度在运动人群中呈上升趋势，但在0.05水平上差异无统计学意义。
The objective of this study was to evaluate the cross-sectional association between physical activity and serum IgG antibodies against selected periodontal microorganisms. The study population consisted of 5,611 randomly selected US adults who participated in the National Health and Nutrition Examination Survey (NHANES) III (1988 to 1994), who were 40 years and older with complete IgG antibody data against 19 oral microorganisms. We used cluster analysis to classify the 19 antibody titers into 4 mutually exclusive groups called “Orange-Red,” “Red-Green,” “Yellow- Orange,” and “Orange-Blue,” and calculated cluster scores by summing antibody titer z-scores for each of the four groups. Physical activity was evaluated based on reported frequency and intensity of physical activity conducted in the last month. Participants were grouped into three categories: adequately physically active, inadequately physically active, and inactive. The outcomes were IgG cluster scores with physical activity as the predictor. Multivariable models adjusted for age, sex, race, smoking status, waist circumference, education, poverty-income-ratio, alcohol, and diabetes. In adjusted models, physical activity was positively associated with the antibodies in the Orange-Blue cluster (E. nodatum, A. naeslundii), a cluster which is associated with healthy periodontal states. The mean differences in cluster scores were 15.2 (95% CI −1.0, 31.4) for Model 3, and 7.0 (95% CI −8.3, 22.3) for Model 4 comparing the sufficiently active group to the inactive group. Antibody titers against periodontal microorganisms reflecting good oral health trended higher among physically active individuals, but the results were not statistically significant at the 0.05 level.