Audiogenic seizures: increased benzodiazepin receptor binding in a susceptible strain of mice.
Audiogenic seizures: increased benzodiazepin receptor binding in a susceptible strain of mice.
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听源性癫痫发作：易感小鼠品系中苯二氮卓受体结合增加。
DOI：
10.1016/0014-2999(80)90149-1
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发表时间：
1980
影响因子：
5
通讯作者：
H. Robertson
中科院分区：
文献类型：
--
作者：
H. Robertson
测定了两个近交系小鼠的脑苯二氮卓受体结合，其中一个品系对听源性惊厥敏感。与年龄匹配、抗癫痫的C57L/6J小鼠相比，易癫痫的DBA/2J品系(约22日龄)的~3H-氟硝西潘的特异性结合率更高。与癫痫敏感性一样，苯二氮卓类药物结合的差异与年龄有关。无论惊厥与否，DBA/2J株均具有较高的苯二氮卓类结合力。在洗涤良好的脑膜碎片中，DBA/2J株的特异性~3H-氟硝西潘结合率也较高，这表明这种差异不是由于存在内源性配体。DBA/2J株的苯二氮卓结合率较高是由于该株的苯二氮卓类受体密度(Bmax)较高所致。这些结果提示，GABA/苯二氮卓类受体复合体的紊乱可能与DBA/2J株的癫痫敏感性有关。
Brain benzodiazepine receptor binding was determined in two inbred strains of mice, one of which is susceptible to audiogenic seizures. Specific binding of3H-flunitrazepam was higher in the seizure-susceptible DBA/2J strain (at about 22 days of age) when compared to age-matched, seizure-resistant C57L/6J mice. Like seizure susceptibility, the differences in benzodiazepine binding were age-related. The DBA/2J strain had higher benzodiazepine binding whether convulsed or not. In well-washed brain membrane fragments specific3H-flunitrazepam binding was also higher in the DBA/2J strain suggesting that the difference was not due to the presence of an endogenous ligand. The higher benzodiazepine binding in the DBA/2J strain was due to a higher benzodiazepine receptor density (Bmax) in this strain. These results suggest that a disorder of the GABA/benzodiazepine receptor complex may be involved in the seizure susceptibility of the DBA/2J strain.