Integrated software environment based on COMKAT for analyzing tracer pharmacokinetics with molecular imaging.
Integrated software environment based on COMKAT for analyzing tracer pharmacokinetics with molecular imaging.
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DOI：
10.2967/jnumed.109.064824
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发表时间：
2010-01
期刊：
影响因子：
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通讯作者：
Muzic RF Jr
中科院分区：
文献类型：
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作者：
Fang YH;Asthana P;Salinas C;Huang HM;Muzic RF Jr
本文介绍了一个综合软件包----Combustion Model Kinetic Analysis Tool（COMKAT）。COMKAT是一个开源软件包，具有将药代动力学分析纳入分子成像研究的许多功能，并具有命令行和图形用户界面。使用COMKAT，用户可以加载和显示图像，绘制感兴趣的区域，加载输入功能，从预定义的列表中选择动力学模型，或创建新的模型并执行参数估计，所有这些都无需编写任何计算机代码。对于图像分析，COMKAT图像工具支持多种图像文件格式，包括医学数字成像和通信（DICOM）标准。图像对比度、缩放、重新切片、显示颜色表和帧总和可以在COMKAT图像工具中进行调整。它还显示并自动配准来自2种模态的图像。提供参数成像能力，并可与分布式计算支持相结合，以提高计算速度。对于没有MATLAB许可证的用户，可以使用COMKAT的编译，可执行版本，尽管它目前只有完整COMKAT功能的一个子集。COMKAT的编译版本和非编译版本均可免费供学术研究使用。大量的文档、示例和COMKAT本身都可以在其基于维基的网站http://comkat.case.edu上找到。鼓励用户贡献，分享他们的经验，例子和COMKAT的扩展。COMKAT具有专门为成像和动力学建模分析设计的集成功能，可用作分子成像和药代动力学分析的软件环境。
An integrated software package, Compartment Model Kinetic Analysis Tool (COMKAT), is presented in this report. COMKAT is an open-source software package with many functions for incorporating pharmacokinetic analysis in molecular imaging research and has both command-line and graphical user interfaces. With COMKAT, users may load and display images, draw regions of interest, load input functions, select kinetic models from a predefined list, or create a novel model and perform parameter estimation, all without having to write any computer code. For image analysis, COMKAT image tool supports multiple image file formats, including the Digital Imaging and Communications in Medicine (DICOM) standard. Image contrast, zoom, reslicing, display color table, and frame summation can be adjusted in COMKAT image tool. It also displays and automatically registers images from 2 modalities. Parametric imaging capability is provided and can be combined with the distributed computing support to enhance computation speeds. For users without MATLAB licenses, a compiled, executable version of COMKAT is available, although it currently has only a subset of the full COMKAT capability. Both the compiled and the noncompiled versions of COMKAT are free for academic research use. Extensive documentation, examples, and COMKAT itself are available on its wiki-based Web site, http://comkat.case.edu. Users are encouraged to contribute, sharing their experience, examples, and extensions of COMKAT. With integrated functionality specifically designed for imaging and kinetic modeling analysis, COMKAT can be used as a software environment for molecular imaging and pharmacokinetic analysis.