The role of estrogen and estrogen receptor-α in male adipose tissue
The role of estrogen and estrogen receptor-α in male adipose tissue
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DOI：
10.1016/s0303-7207(01)00414-2
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发表时间：
2001-06-10
影响因子：
4.1
通讯作者：
Lubahn, DB
中科院分区：
文献类型：
--
作者：
Cooke, PS;Heine, PA;Lubahn, DB
雌激素受体（ER）在白色脂肪组织（WAT）中均有表达，雌激素在调节女性WAT中起重要作用。然而，ER在男性WAT中的作用尚不清楚。在这篇综述中，我们描述了我们的工作，使用野生型（WT）和ER α-敲除（α ERKO）的雄性和雌性小鼠，以确定ER α在调节WAT和吹脂组织（BAT）中的规则。与WT雄性动物相比，α ERKO中WAT随年龄增长而逐渐增加;与WT对照组相比，α ERKO雄性动物成年期各种WAT储存库的重量增加超过100%。相反，所有年龄的α ERKO和WT雄性的BAT体重相似。与WT雄性动物相比，α ERKO的WAT中脂肪细胞面积和数量也增加。与WT对照组相比，α ERKO雌性动物的WAT也有所增加。α ERKO小鼠也有胰岛素抵抗和葡萄糖耐量受损，类似于缺乏ER α或芳香酶的人类。α ERKO男性的肥胖似乎与能量消耗减少有关，而不是与摄食过多有关。总之，ER α缺失导致WAT中脂肪细胞增生和肥大。而不是BAT，并且在男性和女性中都伴有胰岛素抵抗和葡萄糖耐受不良。这些结果首次证明雌激素/ER α信号系统在女性和男性WAT沉积中至关重要，并可能具有临床意义。(C)2001爱思唯尔科学爱尔兰有限公司版权所有。
Males and females both express estrogen receptor (ER) in white adipose tissue (WAT), and estrogens appear to play an important role in regulating WAT in females. However, the role of ER in male WAT was unclear. In this review, we describe our work, which used wild type (WT) and ER alpha -knockout (alpha ERKO) male and female mice to determine the rule of ER alpha in regulating WAT and blown adipose tissue (BAT). There were progressive increases in WAT with advancing age in alpha ERKO compared with WT males; weights of various WAT depots in alpha ERKO males were increased by more than 100% compared with WT controls during adulthood. Conversely, BAT weight was similar in alpha ERKO and WT males at all ages. Adipocyte areas and numbers were also increased in WAT from alpha ERKO compared with WT males. Compared with WT controls, alpha ERKO females also had increases in WAT. The alpha ERKO mice also had insulin resistance and impaired glucose tolerance, similar to humans lacking ER alpha or aromatase. The obesity in alpha ERKO males appeared to involve decreased energy expenditure rather than hyperphagia. In summary, ER alpha absence causes adipocyte hyperplasia and hypertrophy in WAT. but not BAT, and is accompanied by insulin resistance and glucose intolerance in both males and females. These results are the first evidence that the estrogen/ER alpha signaling system is critical in female and male WAT deposition, and may have clinical implications. (C) 2001 Elsevier Science ireland Ltd. All rights reserved.