B cells and B cell products-helping to restore cellular immunity?
B cells and B cell products-helping to restore cellular immunity?
复制标题
B细胞和B细胞产品——帮助恢复细胞免疫力？
DOI：
10.1159/000090196
复制
发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Platt,JeffreyL
中科院分区：
文献类型：
--
作者：
Cascalho,Marilia;Platt,JeffreyL
T cells that provide vital protection against tumors, viruses,and intracellular bacteria are thought to develop independently of B cells. However, recent discoveries suggest that development of T cells depends on B cells. One way B cells promote T cell development is by providing diverse peptides that may promote positive selection of thymocytes. Diverse peptides and B cells help in diversification of the T cell receptor repertoire and may decrease cross-reactivity in the mature T cell compartment. These new insights may provide the basis for the design of novel therapeutics.
