Ku70: A candidate tumor suppressor gene for murine T cell lymphoma
Ku70: A candidate tumor suppressor gene for murine T cell lymphoma
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DOI：
10.1016/s1097-2765(00)80108-2
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发表时间：
1998-07-01
期刊：
影响因子：
16
通讯作者：
Cordon-Cardo, C
中科院分区：
文献类型：
--
作者：
Li, GC;Ouyang, HH;Cordon-Cardo, C
我们提出的证据表明，Ku70基因的失活导致体外和体内恶性转化的倾向。在体外，Ku70（-/-）小鼠成纤维细胞表现出姐妹染色单体交换率增加和自发肿瘤转化的频率高。在体内，Ku70（-/-）小鼠，已知在B淋巴细胞成熟方面有缺陷，但在T淋巴细胞成熟方面没有缺陷，在平均6个月大时发展为胸腺和播散性T细胞淋巴瘤，CD4(+)CD8（+）肿瘤细胞。这些发现直接证明了Ku70缺乏促进肿瘤生长，并提示了Ku70基因座在肿瘤抑制中的新作用。
We present evidence that inactivation of the Ku70 gene leads to a propensity for malignant transformation both in vitro and in vivo. In vitro, Ku70(-/-) mouse fibroblasts displayed an increased rate of sister chromatid exchange and a high frequency of spontaneous neoplastic transformation. In vivo, Ku70(-/-) mice, known to be defective in B but not T lymphocyte maturation, developed thymic and disseminated T cell lymphomas at a mean age of 6 months with CD4(+)CD8(+) tumor cells. These findings directly demonstrate that Ku70 deficiency facilitates neoplastic growth and suggest a novel role of the Ku70 locus in tumor suppression.