The laminin binding integrin alpha6beta1 in prostate cancer perineural invasion.
The laminin binding integrin alpha6beta1 in prostate cancer perineural invasion.
复制标题
DOI：
10.1002/jcp.22149
复制
发表时间：
2010-08
影响因子：
5.6
通讯作者：
Cress AE
中科院分区：
文献类型：
--
作者：
Sroka IC;Anderson TA;McDaniel KM;Nagle RB;Gretzer MB;Cress AE
Metastasizing prostate tumor cells invade along nerves innervating the encapsulated human prostate gland in a process known as perineural invasion. The extacellular matrix laminin class of proteins line the neural route and tumor cells escaping from the gland express the laminin binding integrin α6β1 as a prominent cell surface receptor. Integrin α6β1 promotes aggressive disease and supports prostate tumor cell metastasis to bone. Laminins and their integrin receptors are necessary for the development and maintenance of the peripheral nervous system, indicating the potential role for integrin receptors in directing prostate tumor cell invasion on nerves during perineural invasion.
