Hyperpolarized 3He diffusion MRI and histology in pulmonary emphysema
Hyperpolarized 3He diffusion MRI and histology in pulmonary emphysema
复制标题
DOI：
10.1002/mrm.21076
复制
发表时间：
2006-12-01
影响因子：
3.3
通讯作者：
Hogg, James C.
中科院分区：
文献类型：
--
作者：
Woods, Jason C.;Choong, Cliff K.;Hogg, James C.
超极化He-3的扩散MRI显示，He-3气体的表观扩散系数（ADC）在正常肺中高度受限，在严重肺气肿中几乎不受限制。这种受限扩散的性质提供了有关肺结构的信息;然而，尚未报道与人肺组织学的直接比较。本研究的目的是提供有关He-3气体在肺气肿的人肺中扩散率的信息，并描述He-3扩散率与表面积与肺体积比（SA/V）和平均线性截距（L-m）测量值之间的关系-肺气肿诊断的金标准。通过He-3弥散MRI对接受肺移植治疗晚期COPD的患者的移植肺和未用于移植的供体肺进行成像。在研究位置冷冻后，对相同标本进行组织学测量。扩散率与SAN之间存在负相关性（扩散率与L-m之间存在正相关性）。一个重要的结果是，限制He-3扩散率从肺气肿肺组织更清楚地分离正常比形态分析。这种影响可能是由于与MRI体素尺寸相比，组织学采样尺寸较小。
Diffusion MRI of hyperpolarized He-3 shows that the apparent diffusion coefficient (ADC) of He-3 gas is highly restricted in the normal lung and becomes nearly unrestricted in severe emphysema. The nature of this restricted diffusion provides information about lung structure; however, no direct comparison with histology in human lungs has been reported. The purpose of this study is to provide information about He-3 gas diffusivity in explanted human lungs, and describe the relationship between He-3 diffusivity and the surface area to lung volume ratio (SA/V) and mean linear intercept (L-m) measurements -the gold standard for diagnosis of emphysema. Explanted lungs from patients who were undergoing lung transplantation for advanced COPD, and donor lungs that were not used for transplantation were imaged via He-3 diffusion MRI. Histological measurements were made on the same specimens after they were frozen in the position of study. There is an inverse correlation between diffusivity and SAN (and a positive correlation between diffusivity and L-m). An important result is that restricted He-3 diffusivity separated normal from emphysematous lung tissue more clearly than the morphometric analyses. This effect may be due to the smaller histologic sampling size compared to the MRI voxel sizes.