Expression and prognostic roles of the G1-S modulators in hepatocellular carcinoma: p27 independently predicts the recurrence
Expression and prognostic roles of the G1-S modulators in hepatocellular carcinoma: p27 independently predicts the recurrence
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DOI：
10.1002/hep.510300114
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发表时间：
1999-07-01
期刊：
影响因子：
13.5
通讯作者：
Monden, M
中科院分区：
文献类型：
--
作者：
Ito, Y;Matsuura, N;Monden, M
检测104例肝细胞癌、90例癌旁非癌组织和9例正常肝组织中G(1)-S界面细胞周期调节因子、视网膜母细胞瘤基因产物(PRb)、p21、p16、p27、p53、细胞周期蛋白D-1和细胞周期蛋白E的表达。PRb、p21、p16、p27在肝细胞癌病变中的标记指数(LI)均高于癌旁非癌病变和正常对照。非癌性病变中p27LI显著高于正常肝组织(P=0.011)。P53蛋白异常表达和细胞周期蛋白D-1、E在肝细胞癌组织中呈高表达。PRb阳性率为85.6%，与临床病理参数无关。P21LI总体较低(平均值为5.5+/-9.8)。尽管p21LI是一种负调节因子，但在肝内转移的病例中p21LI水平较高(P=0.0359)。P16LI在晚期患者中显著降低(P=0.0121)。P27LI在有门脉侵犯(P=0.0409)、分化较差(P
Expression of cell-cycle modulators at the G(1)-S boundary, retinoblastoma gene product (pRb), p21, p16, p27, p53, cyclin D-1, and cyclin E was investigated with 104 hepatocellular carcinomas (HCC), as well as 90 of their adjacent noncancerous lesions and 9 normal liver control specimens. The labeling indices (LI) of pRb, p21, p16, and p27 were higher in HCC lesions than in the adjacent noncancerous lesions and normal controls. Especially, p27 LI in noncancerous lesions was significantly higher than that in normal livers (P =.011). Aberrant p53 expression and cyclin D-1 and E overexpression were observed exclusively in HCC lesions. pRb was positive in 85.6% of the HCC cases and was not related to any clinicopathological parameters. The p21 LI was generally low (average, 5.5 +/- 9.8). Although a negative regulator, p21 LI was higher in cases with intrahepatic metastasis (P =.0359). The p16 LI was significantly decreased (P =.0121) in cases with advanced stage. p27 LI was significantly decreased in cases with portal invasion (P =.0409), poor differentiation (P