TGF-β1 Serum Concentration as a Complementary Diagnostic Biomarker of Lung Cancer: Establishment of a Cut-Point Value
TGF-β1 Serum Concentration as a Complementary Diagnostic Biomarker of Lung Cancer: Establishment of a Cut-Point Value
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DOI：
10.1002/jcla.20465
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发表时间：
2011-01-01
影响因子：
2.7
通讯作者：
Gurrola-Diaz, Carmen M.
中科院分区：
文献类型：
--
作者：
Gonzalez-Santiago, Ana E.;Mendoza-Topete, Luz A.;Gurrola-Diaz, Carmen M.
肺癌是一种死亡率不断上升的恶性疾病。细胞因子在正常的细胞生长调节和分化中发挥作用，也与恶性疾病有关。在这些细胞因子中，转化生长因子β1(TGF-β1)在恶性肿瘤细胞中起到肿瘤促进剂的作用。多项临床研究发现，在不同类型的癌症中，转化生长因子-β1水平很高。这项研究的目的是建立一个转化生长因子-β1的临界点，作为肺癌检测的辅助诊断工具。因此，研究对象为72名临床特征良好的个体，41名肺癌患者和31名健康受试者。用双抗体夹心法测定血清转化生长因子-β1浓度。采用方差分析、线性回归和受试者工作曲线分析对两组患者血清转化生长因子-β1水平进行统计学比较。我们观察到肺癌患者产生的转化生长因子-β1水平高于健康人(37,2257+/-9,436比28,4167+/-9,324 pg/ml，P
Lung cancer is a malignant disease with increasing mortality rates. Cytokines play a role in normal cell growth regulation and differentiation and are also implicated in malignant disease. Among these cytokines, Transforming Growth Factor beta type 1 (TGF-beta 1) acts as a tumor promoter in malignant cells. Several clinical studies have found high levels of TGF-beta 1 in various cancer types. The aim of this study was to establish a TGF-beta 1 cut-off point as a complementary diagnostic tool in lung cancer detection. Therefore, 72 clinically well-characterized individuals were studied, 41 lung cancer patients and 31 healthy subjects. Serum TGF-beta 1 concentration was measured by an enzyme-linked immunosorbent assay (ELISA). We compared statistically the serum TGF-beta 1 concentration between both groups with analysis of variance, linear regression and receiver operating curve analysis. We observed that lung cancer patients produced higher TGF-beta 1 levels than healthy individuals (37,2257 +/- 9,436 vs. 28,4167 +/- 9,324 pg/ml, P