SPONTANEOUS FIRING PATTERNS AND AXONAL PROJECTIONS OF SINGLE CORTICOSTRIATAL NEURONS IN THE RAT MEDIAL AGRANULAR CORTEX
SPONTANEOUS FIRING PATTERNS AND AXONAL PROJECTIONS OF SINGLE CORTICOSTRIATAL NEURONS IN THE RAT MEDIAL AGRANULAR CORTEX
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DOI：
10.1152/jn.1994.71.1.17
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发表时间：
1994-01-01
影响因子：
2.5
通讯作者：
WILSON, CJ
中科院分区：
文献类型：
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作者：
COWAN, RL;WILSON, CJ
1.比较了硬膜外麻醉大鼠内侧无颗粒皮质中两种类型皮质纹状体神经元的膜电位自发波动、自发放电模式、树突分支模式以及皮质内和纹状体轴突分支：1）通过髓锥体的逆向激活识别的锥体束（PT）细胞和2）交叉皮质纹状体（CST）通过对侧新纹状体的逆向激活鉴定的神经元。细胞内注射biocytin标记后，细胞内染色的PT神经元以及对侧皮质纹状体神经元的同侧皮质纹状体投射得到证实。2.所有染色良好的PT神经元都有皮质内和纹状体内的侧支。更常见的类型（6 8）是一个大的，深层V神经元，有广泛的皮质内轴突分支，但有限的轴突分支在新纹状体。不太常见的PT神经元类型（2/8）是一个中等大小的，浅层V神经元，有一个有限的皮质内轴突分支，但更大，更密集的纹状体内轴突分支。PT神经元的两个亚类具有与猫和猴的慢PT细胞和传导速度相关的解剖和生理特性
1. Spontaneous fluctuations of membrane potential, patterns of spontaneous firing, dendritic branching patterns, and intracortical and striatal axonal arborizations were compared for two types of corticostriatal neurons in the medial agranular cortex of urethan-anesthetized rats: 1) pyramidal tract (PT) cells identified by antidromic activation from the medullary pyramid and 2) crossed corticostriatal (CST) neurons identified by antidromic activation from the contralateral neostriatum. The ipsilateral corticostriatal projections of intracellularly stained PT neurons as well as contralateral corticostriatal neurons were confirmed after labeling by intracellular injection of biocytin. 2. All well-stained PT neurons had intracortical and intrastriatal collaterals. The more common type (6 of 8) was a large, deep layer V neuron that had an extensive intracortical axon arborization but a limited axon arborization in the neostriatum. The less common type of PT neuron (2 of 8) was a medium-sized, superficial layer V neuron that had a limited intracortical axon arborization but a larger and more dense intrastriatal axonal arborization. Both subclasses of PT neurons had anatomic and physiological properties associated with slow PT cells in cats and monkeys and conduction velocities