Mild cognitive impairment: differential atrophy in the hippocampal subfields.
Mild cognitive impairment: differential atrophy in the hippocampal subfields.
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轻度认知障碍：海马子场中的差异萎缩。
DOI：
10.3174/ajnr.a2589
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发表时间：
2011-10
期刊：
影响因子：
--
通讯作者：
Ivanoiu A
中科院分区：
文献类型：
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作者：
Hanseeuw BJ;Van Leemput K;Kavec M;Grandin C;Seron X;Ivanoiu A
海马体积测定是诊断阿尔茨海默病的有用替代标志物，但它对于 aMCI 阶段似乎不够敏感。我们假设一些海马亚区在 aMCI 中特别萎缩，测量海马亚区体积将提高 MR 成像检测 aMCI 的灵敏度。我们评估了 15 名 aMCI 患者和 15 名匹配对照者的情景记忆和海马亚区体积。在从临床 MR 成像中分割整个海马体后，我们应用了一种新的计算方法，可以实现海马体子区域的全自动分割。该方法使用贝叶斯建模方法从成像数据推断分割。与对照组相比，aMCI 患者的下托和 CA2-3 显着萎缩，而海马总体积和其他亚区则没有。对照组的海马总体积与年龄相关，而情景记忆是 aMCI 患者海马总体积和萎缩子区域的主要解释变量。细分子字段可将诊断 aMCI 的敏感性从 40% 提高到 73%。测量 CA2-3 和下托体积可以更好地检测 aMCI。
Hippocampus volumetry is a useful surrogate marker for the diagnosis of Alzheimer disease, but it seems insufficiently sensitive for the aMCI stage. We postulated that some hippocampus subfields are specifically atrophic in aMCI and that measuring hippocampus subfield volumes will improve sensitivity of MR imaging to detect aMCI. We evaluated episodic memory and hippocampus subfield volume in 15 patients with aMCI and 15 matched controls. After segmentation of the whole hippocampus from clinical MR imaging, we applied a new computational method allowing fully automated segmentation of the hippocampus subfields. This method used a Bayesian modeling approach to infer segmentations from the imaging data. In comparison with controls, subiculum and CA2–3 were significantly atrophic in patients with aMCI, whereas total hippocampus volume and other subfields were not. Total hippocampus volume in controls was age-related, whereas episodic memory was the main explanatory variable for both the total hippocampus volume and the subfields that were atrophic in patients with aMCI. Segmenting subfields increases sensitivity to diagnose aMCI from 40% to 73%. Measuring CA2–3 and subiculum volumes allows a better detection of aMCI.