Current hydrogel solutions for repairing and regeneration of complex tissues.
Current hydrogel solutions for repairing and regeneration of complex tissues.
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DOI：
10.2174/0929867321666131212151855
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发表时间：
2014-06
影响因子：
4.1
通讯作者：
Y. Wang;L. Cai;B. Nugraha;Y. Gao;H. Leo
中科院分区：
文献类型：
--
作者：
Y. Wang;L. Cai;B. Nugraha;Y. Gao;H. Leo
水凝胶系统作为一种重要的生物材料，因其具有广泛的生物化学和物理特性而在再生医学领域具有巨大的应用潜力，如与重要组织中的基本生物分子的生物相容性、高保水性和可调节的软组织样物理化学特性等。这些性质是可改变的，以促进保护靶组织免受外部损伤干扰，并具有原位诱导或维持的包封细胞的生理功能表型。最近，水凝胶越来越多地用于再生医学的研发，以构建复杂的组织。大多数有见地的工作集中在如何选择和制造具有所需物理化学性质的水凝胶模型，对各种生物刺激的自动响应的灵活性，以及在不同尺度下有效形成复杂组织模拟结构的能力。本文介绍了水凝胶的主要类型、理想的物理化学性质、目前的制备方法以及水凝胶在复杂组织工程中的特殊应用。此外，本文还讨论了水凝胶系统在复杂组织医学研究中面临的主要障碍。
Hydrogel system, as one of the most important biomaterials, is widely studied because of its tremendous potential in regenerative medicine conferred by its wide range of malleable biochemical and physical characteristics, which include its biocompatibility with the elemental biomolecules in vital tissues, its high water retention capability and adjustable soft-tissue-like physicochemical properties. These properties are modifiable to facilitate the targeted tissue protected from external damaging disturbance and having the encapsulated cells' physiology-functional phenotypes induced or maintained in situ. Recently, hydrogels are increasingly used in the R&D of regenerative medicine to build complex tissue. Most of the insightful work focuses on how to select and fabricate the hydrogel models with desired physicochemical properties, flexibility of auto response to various bio-stimuli, and capability of efficiently forming the complex tissue-mimicking construct at different scales. The present review introduced the major types of hydrogeis, the desirable physicochemical properties, the current fabrication methodologies and special organ-based cases of applications of hydrogels, which are used in complex tissue engineering. In addition, this review also discussed the major hurdles faced by the R&D of hydrogel systems for complex tissue medicine.