Posttraumatic stress disorder increases risk for suicide attempt in adults with recurrent major depression.
Posttraumatic stress disorder increases risk for suicide attempt in adults with recurrent major depression.
复制标题
DOI：
10.1002/da.22160
复制
发表时间：
2013-10
影响因子：
7.4
通讯作者：
Potash, James B.
中科院分区：
文献类型：
--
作者：
Stevens, Daniel;Wilcox, Holly C.;MacKinnon, Dean F.;Mondimore, Francis M.;Schweizer, Barbara;Jancic, Dunya;Coryell, William H.;Weissman, Myrna M.;Levinson, Douglas F.;Potash, James B.
复发性早发性抑郁症的遗传学研究（GenRED II）数据被用来研究创伤后应激障碍（PTSD）和自杀未遂之间的关系，在1,433例复发性早发性重度抑郁症（MDD）患者中。我们检验了攻击性创伤导致的PTSD增加复发性MDD患者自杀未遂风险的假设。使用3.0版遗传学研究诊断访谈收集终生创伤暴露和临床症状的数据，并报告MDD、PTSD和其他DSM-IV轴I疾病的最佳估计诊断以及最佳估计发病年龄。该样本中自杀企图的终生患病率为28%。在205名（14.3%）参与者中诊断出终身PTSD。我们使用离散时间生存分析来考虑PTSD-自杀企图关系中的时间，同时调整人口统计学变量（性别，种族，年龄和教育水平）和创伤暴露前的共病诊断。PTSD是随后自杀企图的独立预测因子（HR = 2.5，95%CI：1.6，3.8; P <0.0001）。无论是攻击性或非攻击性创伤没有PTSD显着预测随后的自杀企图后Bonferroni校正。创伤后应激障碍和随后的自杀企图之间的关联是由涉及攻击性暴力的创伤事件驱动的（HR = 1.7，95%CI：1.3，2.2; P < .0001）。在复发性MDD患者中，PTSD似乎是创伤事件适应不良反应的脆弱性标志，也是自杀未遂的独立风险因素。进一步研究PTSD患者和非PTSD患者在生物学指标上的差异可能会揭示这种潜在的脆弱性
Genetics of Recurrent Early-Onset Depression study (GenRED II) data were used to examine the relationship between posttraumatic stress disorder (PTSD) and attempted suicide in a population of 1,433 individuals with recurrent early-onset major depressive disorder (MDD). We tested the hypothesis that PTSD resulting from assaultive trauma increases risk for attempted suicide among individuals with recurrent MDD. Data on lifetime trauma exposures and clinical symptoms were collected using the Diagnostic Interview for Genetic Studies version 3.0 and best estimate diagnoses of MDD, PTSD, and other DSM-IV Axis I disorders were reported with best estimated age of onset. The lifetime prevalence of suicide attempt in this sample was 28%. Lifetime PTSD was diagnosed in 205 (14.3%) participants. We used discrete time-survival analyses to take into account timing in the PTSD-suicide attempt relationship while adjusting for demographic variables (gender, race, age, and education level) and comorbid diagnoses prior to trauma exposure. PTSD was an independent predictor of subsequent suicide attempt (HR = 2.5, 95% CI: 1.6, 3.8; P < .0001). Neither assaultive nor nonassaultive trauma without PTSD significantly predicted subsequent suicide attempt after Bonferroni correction. The association between PTSD and subsequent suicide attempt was driven by traumatic events involving assaultive violence (HR = 1.7, 95% CI: 1.3, 2.2; P < .0001). Among those with recurrent MDD, PTSD appears to be a vulnerability marker of maladaptive responses to traumatic events and an independent risk factor for attempted suicide. Additional studies examining differences between those with and without PTSD on biological measures might shed light on this potential vulnerability
登录
查看更多内容
影响因子：
--
作者：
Sartor, Carolyn E.;Grant, Julia D.;Lynskey, Michael T.;McCutcheon, Vivia V.;Waldron, Mary;Statham, Dixie J.;Bucholz, Kathleen K.;Madden, Pamela A. F.;Heath, Andrew C.;Martin, Nicholas G.;Nelson, Elliot C.
通讯作者：
Nelson, Elliot C.
影响因子：
1.2
作者：
Teten, Andra L.;Miller, Lisa A.;Kent, Thomas A.
通讯作者：
Kent, Thomas A.
影响因子：
3.7
作者：
Stein DJ;Chiu WT;Hwang I;Kessler RC;Sampson N;Alonso J;Borges G;Bromet E;Bruffaerts R;de Girolamo G;Florescu S;Gureje O;He Y;Kovess-Masfety V;Levinson D;Matschinger H;Mneimneh Z;Nakamura Y;Ormel J;Posada-Villa J;Sagar R;Scott KM;Tomov T;Viana MC;Williams DR;Nock MK
通讯作者：
Nock MK
影响因子：
158.5
作者：
WEISSMAN, MM;KLERMAN, GL;OUELLETTE, R
通讯作者：
OUELLETTE, R
影响因子：
12.7
作者：
Zivin, Kara;Kim, Myra;Valenstein, Marcia
通讯作者：
Valenstein, Marcia