SPP1 is a prognostic related biomarker and correlated with tumor-infiltrating immune cells in ovarian cancer.
SPP1 is a prognostic related biomarker and correlated with tumor-infiltrating immune cells in ovarian cancer.
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DOI：
10.1186/s12885-022-10485-8
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发表时间：
2022-12-30
期刊：
影响因子：
3.8
通讯作者：
中科院分区：
文献类型：
--
作者：
分泌型磷蛋白1（Secreted phosphoprotein 1，SPP 1）在多种肿瘤的发生、发展过程中起着重要作用，但SPP 1在卵巢癌免疫浸润调节中究竟是旁观者还是实际参与者，仍有待进一步研究。本研究通过Oncomine、GEPIA和TIMER数据库对SPP 1的表达水平进行鉴定，并通过HPA数据库获得SPP 1免疫组化染色结果。通过Kaplan-Meier Plotter和PrognoScan数据集评估SPP 1表达水平对卵巢癌患者临床结局的影响。使用TIMER和TISIDB数据集进行免疫浸润分析。此外，使用Metascape和GeneMANIA数据库进行功能富集分析。为了从公共数据库中验证这些发现，在一组卵巢癌患者中验证了这些结果。发现SPP 1在卵巢肿瘤组织中过表达，并且SPP 1高表达与较短的生存期相关。值得注意的是，SPP 1表达与CD 4 + T细胞、CD 8 + T细胞、巨噬细胞、中性粒细胞和树突状细胞的浸润水平呈正相关。此外，SPP 1表达水平与卵巢癌中不同的免疫细胞有很强的相关性。值得注意的是，功能富集分析表明SPP 1与免疫应答强烈相关。这些发现表明SPP 1与预后和免疫细胞浸润相关，为卵巢癌提供了一个新的潜在免疫靶点。不适用因在线版本包含补充材料，可通过10.1186/s12885-022-10485-8获得。
Secreted phosphoprotein 1 (SPP1) plays a vital role in tumor progression of multiple cancer types However, it still awaits further exploration whether SPP1 is a bystander or an actual player in the modulation of immune infiltration in ovarian cancer. In this study, the expression level of SPP1 was identified by Oncomine, GEPIA and TIMER databases, and the result of SPP1 immumohistochemical staining was acquired by The HPA database. The impact of SPP1 expression level on the clinical outcome of ovarian cancer patients were evaluated via Kaplan–Meier Plotter and PrognoScan dataset. Immune infiltration analyses were conducted using TIMER and TISIDB dataset. In addition, Functional enrichment analyses were performed with Metascape and GeneMANIA database. To verify these findings from the public database, the results were validated in a cohort of ovarian cancer patients. SPP1 was found to be overexpressed in ovarian tumor tissues and high SPP1 expression was correlated with shorter survivals. Notably, SPP1 expression was positively correlated with infiltrating levels of CD4 + T cells, CD8 + T cells, macrophages, neutrophils, and dendritic cells. Furthermore, SPP1 expression level showed strong correlation with diverse immune cells in ovarian cancer. Of note, functional enrichment analysis suggested that SPP1 was strongly correlated with immune response. These findings imply that SPP1 is correlated with prognosis and immune cell infiltrating, offering a new potential immunotherapeutic target in ovarian cancer. Not applicable. The online version contains supplementary material available at 10.1186/s12885-022-10485-8.
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影响因子：
45.3
作者：
Azimi, Farhad;Scolyer, Richard A.;Thompson, John F.
通讯作者：
Thompson, John F.
DOI：
10.1073/pnas.83.23.8819
发表时间：
1986-12-01
影响因子：
11.1
作者：
OLDBERG, A;FRANZEN, A;HEINEGARD, D
通讯作者：
HEINEGARD, D
DOI：
10.1056/nejmoa1200694
发表时间：
2012-06-28
期刊：
The New England journal of medicine
影响因子：
--
作者：
Brahmer JR;Tykodi SS;Chow LQ;Hwu WJ;Topalian SL;Hwu P;Drake CG;Camacho LH;Kauh J;Odunsi K;Pitot HC;Hamid O;Bhatia S;Martins R;Eaton K;Chen S;Salay TM;Alaparthy S;Grosso JF;Korman AJ;Parker SM;Agrawal S;Goldberg SM;Pardoll DM;Gupta A;Wigginton JM
通讯作者：
Wigginton JM
影响因子：
3.6
作者：
Kolb, A;Kleeff, J;Friess, H
通讯作者：
Friess, H
DOI：
10.1083/jcb.201510086
发表时间：
2016-04-25
期刊：
The Journal of cell biology
影响因子：
--
作者：
Capote J;Kramerova I;Martinez L;Vetrone S;Barton ER;Sweeney HL;Miceli MC;Spencer MJ
通讯作者：
Spencer MJ