A focus on CXCR4 in Alzheimer's disease.
A focus on CXCR4 in Alzheimer's disease.
复制标题
DOI：
10.4103/bc.bc_13_17
复制
发表时间：
2017-10-01
影响因子：
1.9
通讯作者：
Wang, Rong
中科院分区：
文献类型：
--
作者：
Li, Hongyan;Wang, Rong
阿尔茨海默病(AD)是最常见、最具破坏性的衰老相关神经退行性疾病之一。除了已知的趋化因子及其受体在免疫系统中的作用外，它们在神经系统中也广泛表达，在调节细胞迁移和神经传递方面发挥作用。趋化因子CXC基序受体4(CXCR4)是进化上高度保守的七跨膜G蛋白偶联受体(GPCRs)。已有研究证明CXCL12/CXCR4信号通路参与了AD的病理过程。本文就CXCR4与GPCR3、CXCR4与AD的关系作一综述。该综述旨在为轻度认知障碍的早期预防以及AD的诊断和治疗提供新的见解。
Alzheimer's disease (AD) is one of the most common and devastating aging-related neurodegenerative diseases. Besides the well-known role of chemokines and their receptors in the immune system, they are widely expressed in the nervous system, where they play roles in the regulation of cell migration and neurotransmission. The chemokine CXC motif receptor 4 (CXCR4) is evolutionarily highly conserved seven-transmembrane G-protein-coupled receptors (GPCRs). It has been demonstrated that CXCL12/CXCR4 signaling pathway involved in the pathologic process of AD. In this review, we demonstrated the GPCR family proteins and summarized the relationship between CXCR4 and GPCR, CXCR4 and AD. The review aimed to provide the novel insight of CXCR4 into the early prevention of mild cognitive impairment and in the diagnosis and treatment of AD.